Zhang Jiahe, Chen Danlei, Deming Philip, Srirangarajan Tara, Theriault Jordan, Kragel Philip A, Hartley Ludger, Lee Kent M, McVeigh Kieran, Wager Tor D, Wald Lawrence L, Satpute Ajay B, Quigley Karen S, Whitfield-Gabrieli Susan, Barrett Lisa Feldman, Bianciardi Marta
Department of Psychology, Northeastern University, Boston, MA 02115.
Department of Psychology, Stanford University, Stanford, CA 94305.
bioRxiv. 2025 Jan 13:2023.07.20.548178. doi: 10.1101/2023.07.20.548178.
The brain continuously anticipates the energetic needs of the body and prepares to meet those needs before they arise, called allostasis. In support of allostasis, the brain continually models the sensory state of the body, called interoception. We replicated and extended a large-scale system supporting allostasis and interoception in the human brain using ultra-high precision 7 Tesla functional magnetic resonance imaging (fMRI) ( = 90), improving the precision of subgenual and pregenual anterior cingulate topography combined with extensive brainstem nuclei mapping. We observed over 90% of the anatomical connections published in tract-tracing studies in non-human animals. The system also included regions of dense intrinsic connectivity broadly throughout the system, some of which were identified previously as part of the backbone of neural communication across the brain. These results strengthen previous evidence for a whole-brain system supporting the modeling and regulation of the internal milieu of the body.
大脑持续预测身体的能量需求，并在需求出现之前做好满足这些需求的准备，这一过程称为应变稳态。为支持应变稳态，大脑不断模拟身体的感觉状态，即内感受。我们使用超高精度7特斯拉功能磁共振成像（fMRI）（n = 90）复制并扩展了一个支持人类大脑应变稳态和内感受的大规模系统，提高了膝下和膝前扣带回地形的精度，并结合了广泛的脑干核映射。我们观察到在非人类动物的束路追踪研究中发表的解剖连接中有90%以上。该系统还包括整个系统中广泛的密集内在连接区域，其中一些区域先前被确定为全脑神经通信主干的一部分。这些结果强化了先前的证据，即存在一个支持身体内部环境建模和调节的全脑系统。
