Sun Juan, Yue Chenyang, Liu Zhen, Li Jie, Kang Weiming
Division of General Surgery, Department of Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Department of Biology, York University, Toronto, ON, Canada.
Front Nutr. 2022 May 20;9:851280. doi: 10.3389/fnut.2022.851280. eCollection 2022.
Serum uric acid (SUA) has been proven to be closely associated with metabolic abnormalities, including obesity. This study aimed to investigate the detailed relationship between total percent fat (TPF) and SUA among adults.
Briefly, 23,715 adults aged 18-59 years in the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included in this study. Multivariable linear regression models were used to examine the association between TPF and SUA. Subgroup analyses stratified by sex and obesity status were also performed by multivariable linear regression. Then, fitted smoothing curves and generalized additive models were also applied to address the non-linear relationship between TPF and SUA. Finally, a recursive algorithm was used to calculate the inflection point in the non-linear relationship and a two-segment piecewise linear regression model was used to analyze the relationship between TPF and SUA on both sides of the inflection point.
There were 15,808 (66.7%) obese individuals in all 23,715 participants. In the fully adjusted model, there was a positive association between TPF and SUA (β = 0.99, 95% CI: 0.73-1.26). Besides, this positive association remained statistically significant in subgroup analyses stratified by sex and obesity status. Interestingly, in males, the association of TPF and SUA was an inverted U-shaped curve (inflection point: 34.3%).
Our study revealed a significant positive relationship between TPF and SUA among adults and this association remained statistically significant when stratified by sex and obesity status, but the shape of the smoothing curve in males differed from that in females.
血清尿酸（SUA）已被证明与包括肥胖在内的代谢异常密切相关。本研究旨在调查成年人中总脂肪百分比（TPF）与SUA之间的详细关系。
简而言之，本研究纳入了1999 - 2018年美国国家健康与营养检查调查（NHANES）中的23715名18 - 59岁的成年人。采用多变量线性回归模型来检验TPF与SUA之间的关联。还通过多变量线性回归对按性别和肥胖状态分层的亚组进行了分析。然后，应用拟合平滑曲线和广义相加模型来处理TPF与SUA之间的非线性关系。最后，使用递归算法计算非线性关系中的拐点，并使用两段式分段线性回归模型分析拐点两侧TPF与SUA之间的关系。
在所有23715名参与者中，有15808名（66.7%）肥胖个体。在完全调整模型中，TPF与SUA之间存在正相关（β = 0.99，95%CI：0.73 - 1.26）。此外，在按性别和肥胖状态分层的亚组分析中，这种正相关仍然具有统计学意义。有趣的是，在男性中，TPF与SUA的关联呈倒U形曲线（拐点：34.3%）。
我们的研究揭示了成年人中TPF与SUA之间存在显著的正相关关系，并且在按性别和肥胖状态分层时，这种关联仍然具有统计学意义，但男性的平滑曲线形状与女性不同。
