Takagishi K, Kaibara N, Hotokebuchi T, Arita C, Morinaga M, Arai K
Ann Rheum Dis. 1986 Apr;45(4):339-44. doi: 10.1136/ard.45.4.339.
We have studied the effect of the immunosuppressive agent cyclosporin on collagen induced arthritis in mice. Cyclosporin, when given prophylactically, was capable of suppressing the development of collagen induced arthritis and the immunological response to native type II collagen in a dose dependent manner. Furthermore, treatment with cyclosporin, started on the same day as the booster injection with type II collagen, also resulted in inhibition of development of arthritis and of immunity to collagen. These findings suggest that the time of a booster injection, three weeks after the initial immunisation, might be still within the induction phase of arthritis since reinoculation is required to produce a high incidence of arthritis in mice. In addition, therapeutic treatment with cyclosporin did not affect the clinical course of the disease or the immune response to collagen.
我们研究了免疫抑制剂环孢素对小鼠胶原诱导性关节炎的影响。预防性给予环孢素能够以剂量依赖的方式抑制胶原诱导性关节炎的发展以及对天然II型胶原的免疫反应。此外，在与II型胶原加强注射同一天开始用环孢素治疗，也能抑制关节炎的发展和对胶原的免疫反应。这些发现表明，在初次免疫三周后进行加强注射的时间，可能仍处于关节炎的诱导期，因为需要再次接种才能在小鼠中产生高发病率的关节炎。此外，用环孢素进行治疗性处理并不影响疾病的临床进程或对胶原的免疫反应。
