转化生长因子β1对小鼠实验性自身免疫性疾病的保护作用。
Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.
作者信息
Kuruvilla A P, Shah R, Hochwald G M, Liggitt H D, Palladino M A, Thorbecke G J
机构信息
Department of Pathology, Kaplan Cancer Center, New York University School of Medicine, NY 10016.
出版信息
Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2918-21. doi: 10.1073/pnas.88.7.2918.
Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown that microgram amounts of TGF-beta 1, injected daily for 1-2 weeks, protect against collagen-induced arthritis (CIA) and relapsing experimental allergic encephalomyelitis (REAE), the animal models for rheumatoid arthritis and multiple sclerosis, respectively. When administered during induction of the disease, TGF-beta 1 prevents CIA but only delays the onset of REAE by 2-3 days. However, when administered during a remission. TGF-beta 1 prevents the occurrence of relapses in REAE. The results suggest that TGF-beta 1 has powerful anti-inflammatory effects, mimicking in some respects the beneficial effects of immunosuppressive drugs in these experimental models of autoimmune disease, but without discernable adverse effects.
白细胞介素1（IL-1）和肿瘤坏死因子α被认为与自身免疫性疾病相关的炎症反应有关。转化生长因子β1（TGF-β1）可抵消这些细胞因子的许多作用，并具有多种免疫抑制特性。在本研究中，结果表明，每天注射微克量的TGF-β1，持续1至2周，可预防胶原诱导的关节炎（CIA）和复发性实验性过敏性脑脊髓炎（REAE），这两种分别是类风湿性关节炎和多发性硬化症的动物模型。在疾病诱导期间给予TGF-β1可预防CIA，但仅将REAE的发病延迟2至3天。然而，在缓解期给予TGF-β1可预防REAE复发。结果表明，TGF-β1具有强大的抗炎作用，在某些方面模拟了免疫抑制药物在这些自身免疫性疾病实验模型中的有益作用，但没有明显的不良反应。
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