Wu Yuyu, Zhao Ke, Chen Yingjie, Wu Liujun, Qiu Feng, Yuan Yuying, Shen Guanghui, Wang Kexin, Kang Yimin, Jiang Yongsheng, Wang Wei, Chen Li, Liu Yanlong, Pan Xuebo, Wang Fan, Xie Longteng
Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, Wenzhou, China.
School of Mental Health, Wenzhou Medical University, Wenzhou, China.
Front Psychiatry. 2023 Jul 21;14:1111712. doi: 10.3389/fpsyt.2023.1111712. eCollection 2023.
Alcohol use disorder (AUD) is the second most prevalent mental disorder and might be related to depression. Major vault protein (MVP) is a cytoplasmic protein related to vesicle transport. The present study aimed to investigate the interaction between a genetic variant (MVP rs4788186) and depression in adult male Han Chinese with AUD during withdrawal.
All participants ( = 435) were diagnosed with AUD. Alcohol dependence level was measured using the Michigan Alcoholism Screening Test, and depression was measured using the self-rating depression scale. Genomic DNA was extracted from peripheral blood and genotyped.
Hierarchical regression analysis identified an interaction between MVP rs4788186 and alcohol dependence level for depression ( = -0.17, < 0.05). Then, a region of significance test was performed to interpret the interaction effect. Re-parameterized regression models revealed that the interaction between MVP rs4788186 and alcohol problem severity fit the strong differential susceptibility model ( = 0.08, < 0.001), suggesting that the AA homozygotes would be more likely subjects with the G allele to experience major depression symptoms.
Carriers of the AA homozygote of MVP rs4788186 may be more susceptible to severe alcohol problems and higher levels of depression during withdrawal.
酒精使用障碍（AUD）是第二常见的精神障碍，可能与抑郁症有关。主要穹窿蛋白（MVP）是一种与囊泡运输相关的细胞质蛋白。本研究旨在调查成年男性汉族AUD患者戒断期间基因变异（MVP rs4788186）与抑郁症之间的相互作用。
所有参与者（n = 435）均被诊断为AUD。使用密歇根酒精ism筛查测试测量酒精依赖水平，使用自评抑郁量表测量抑郁症。从外周血中提取基因组DNA并进行基因分型。
分层回归分析确定了MVP rs4788186与酒精依赖水平对抑郁症的相互作用（β = -0.17，p < 0.05）。然后，进行了显著性区域测试以解释相互作用效应。重新参数化的回归模型显示，MVP rs4788186与酒精问题严重程度之间的相互作用符合强差异易感性模型（R² = 0.08，p < 0.001），表明AA纯合子比携带G等位基因的受试者更易出现重度抑郁症状。
MVP rs4788186的AA纯合子携带者在戒断期间可能更容易出现严重的酒精问题和更高水平的抑郁症。
