Huzhou Third People's Hospital, Zhejiang, China.
Department of Pharmacy, Ningbo Medical Treatment Center, Li Huili Hospital, Ningbo, China.
J Clin Lab Anal. 2023 Jun;37(11-12):e24933. doi: 10.1002/jcla.24933. Epub 2023 Jun 30.
Previous studies suggest that alcohol dependence is associated with increased risk of depression. The occurrence of depressive symptoms is related to polymorphisms in various genetic regions. This study aimed to investigate the interaction of RETN gene polymorphisms (rs1477341, rs3745368) with alcohol dependence on depressive symptoms in adult male during acute alcohol withdrawal.
A total of 429 male adults were recruited in this study. Alcohol dependence was assessed using the Michigan alcoholism screening test (MAST). Depression was assessed using the 20-item self-rating depression scale (SDS). Hierarchical regression analysis was used to evaluate the interaction between genes and alcohol dependence on depression. Region of significance (ROS) test was used to explain the interaction effect. The strong and weak forms of the differential susceptibility and diathesis models were used to determine which fits the data better.
Our results showed that MAST scores were significantly positively associated with SDS scores (r = 0.23, p < 0.01) in alcohol-dependent patients during alcohol withdrawal. The interaction between genotype and alcohol dependence was significant (β = -0.14, p < 0.05) in a strong diathesis-stress model. Susceptibility for depression symptoms was associated with alcohol dependence in RETN rs1477341 A carriers. Specifically, those that showed more alcohol dependence and the A allele of RETN rs1477341 exhibited more depression symptoms. However, RETN rs3745368 had no significant interaction with alcohol dependence.
The A allele of RETN rs1477341 may correlate with susceptibility to depression symptoms in alcohol-dependent individuals during acute alcohol withdrawal.
先前的研究表明，酒精依赖与抑郁风险增加有关。抑郁症状的发生与各种遗传区域的多态性有关。本研究旨在探讨 RETN 基因多态性（rs1477341、rs3745368）与急性酒精戒断期间成年男性酒精依赖对抑郁症状的相互作用。
本研究共招募了 429 名成年男性。使用密歇根酒精中毒筛查测试（MAST）评估酒精依赖。使用 20 项自评抑郁量表（SDS）评估抑郁。采用层次回归分析评估基因与酒精依赖对抑郁的相互作用。采用显著区域（ROS）检验解释相互作用效应。采用差异易感性和素质模型的强弱形式来确定哪个更适合数据。
我们的结果表明，在酒精依赖患者急性酒精戒断期间，MAST 评分与 SDS 评分呈显著正相关（r=0.23，p<0.01）。在强素质-应激模型中，基因型与酒精依赖之间的相互作用具有显著性（β=-0.14，p<0.05）。抑郁症状的易感性与 RETN rs1477341 的 A 等位基因有关。具体来说，那些表现出更多的酒精依赖和 RETN rs1477341 的 A 等位基因表现出更多的抑郁症状。然而，RETN rs3745368 与酒精依赖无显著相互作用。
RETN rs1477341 的 A 等位基因可能与急性酒精戒断期间酒精依赖个体的抑郁症状易感性相关。
