Elboraey Mohamed Omar, Sabra Reda Saber, Gamal Sherouk Mohamed Mohamed
Department Oral Medicine, Periodontology, Oral Diagnosis and Radiology, Faculty of Dentistry, Tanta University, Tanta, Egypt.
Contemp Clin Dent. 2023 Apr-Jun;14(2):135-140. doi: 10.4103/ccd.ccd_183_22. Epub 2023 Jun 30.
Periodontitis causes the destruction of soft and hard tissues. Stem cells have immense potential in regenerative cellular therapy. This clinical trial aimed to evaluate clinically and radiographically the effectiveness of the local application of Edelweiss stem cells as a nonsurgical treatment for stage III periodontitis.
The trial included 40 periodontal pockets in participants who have stage III periodontitis with probing pocket depth (PPD) ≥5 mm and clinical attachment loss (CAL) ≥5 mm. Pockets were randomly divided into two groups Group 1: was given oral hygiene instruction, scaling, root planing, and subgingival application of plant stem cells on gel foam carrier after that a periodontal dressing was applied. The procedures were repeated after 2 weeks. Group 2: was treated only by scaling and root planing. Gingival index, CAL, and PPD were measured at baseline and 3 months' posttherapy. The radiographical evaluation was done by digital long-cone parallel periapical radiographs at baseline and 6 months posttherapy.
Clinical parameters for both groups showed a statistically significant improvement. Regarding radiographic evaluation, there was a significant increase in bone density in favor of the study group.
Locally applied Edelweiss stem cells can be considered a promising nonsurgical treatment modality for periodontal regeneration.
牙周炎会导致软硬组织的破坏。干细胞在再生细胞治疗中具有巨大潜力。本临床试验旨在从临床和影像学角度评估局部应用雪绒花干细胞作为III期牙周炎非手术治疗方法的有效性。
该试验纳入了40个牙周袋的参与者，这些参与者患有III期牙周炎，探诊深度（PPD）≥5mm，临床附着丧失（CAL）≥5mm。牙周袋被随机分为两组。第1组：接受口腔卫生指导、龈上洁治、根面平整，并在凝胶泡沫载体上进行植物干细胞的龈下应用，之后应用牙周敷料。2周后重复这些操作。第2组：仅接受龈上洁治和根面平整治疗。在基线和治疗后3个月测量牙龈指数、CAL和PPD。影像学评估在基线和治疗后6个月通过数字化长锥平行根尖片进行。
两组的临床参数均显示出统计学上的显著改善。在影像学评估方面，研究组的骨密度有显著增加。
局部应用雪绒花干细胞可被视为一种有前景的牙周再生非手术治疗方式。
