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通过转录组分析研究（雪绒花）愈伤组织提取物的抗衰老作用。

Anti-Aging Effects of (Edelweiss) Callus Culture Extract Through Transcriptome Profiling.

机构信息

Research Institute of Agriculture and Life Sciences, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

Anti-Aging Research Institute of BIO-FD&C Co., Ltd., Incheon 21990, Korea.

出版信息

Genes (Basel). 2020 Feb 21;11(2):230. doi: 10.3390/genes11020230.

DOI:10.3390/genes11020230
PMID:32098197
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7074254/
Abstract

Edelweiss () in the family is a wildflower that grows in rocky limestone places. Here, we investigated the efficacy of edelweiss callus culture extract ( callus culture extract; LACCE) using multiple assays from to as well as transcriptome profiling. Several assay results showed the strong antioxidant activity of LACCE in response to UVB treatment. Moreover, LACCE suppressed inflammation and wrinkling; however, moisturizing activity was increased by LACCE. The clinical test demonstrated that constant application of LACCE on the face and skin tissues improved anti-periorbital wrinkles, skin elasticity, dermal density, and skin thickness compared with the placebo. The RNA-Sequencing results showed at least 16.56% of human genes were expressed in keratinocyte cells. LACCE up-regulated genes encoding several KRT proteins; DDIT4, BNIP3, and IGFBP3 were involved in the positive regulation of the developmental process, programmed cell death, keratinization, and cornification forming skin barriers, which provide many advantages in the human skin. By contrast, down-regulated genes were stress-responsive genes, including metal, oxidation, wounding, hypoxia, and virus infection, suggesting LACCE did not cause any harmful stress on the skin. Our comprehensive study demonstrated LACCE is a promising agent for anti-aging cosmetics.

摘要

雪绒花（Edelweiss）属于报春花科，是一种生长在多石的石灰质土壤中的野生花卉。在这里，我们使用多种方法从 到 研究了雪绒花愈伤组织提取物（callus culture extract；LACCE）的功效，并进行了转录组分析。几项 assay 结果表明，LACCE 具有很强的抗氧化活性，能够抵御 UVB 处理的伤害。此外，LACCE 能够抑制炎症和皱纹的形成，同时增加皮肤的保湿能力。临床试验 表明，与安慰剂相比，持续将 LACCE 涂抹在面部和皮肤组织上，能够显著改善眼周皱纹、皮肤弹性、真皮密度和皮肤厚度。RNA-Sequencing 结果表明，LACCE 至少能使 16.56%的人类基因在角质形成细胞中表达。LACCE 上调了编码多种 KRT 蛋白的基因；DDIT4、BNIP3 和 IGFBP3 参与了细胞程序性死亡、角化和表皮屏障形成等皮肤发育过程的正向调控，为人类皮肤提供了许多优势。相比之下，下调的基因是应激反应基因，包括金属、氧化、创伤、缺氧和病毒感染，这表明 LACCE 不会对皮肤造成任何有害的应激。我们的综合研究表明，LACCE 是一种有前途的抗衰老化妆品原料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/ebf756ad6c70/genes-11-00230-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/2c49ee30a615/genes-11-00230-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/c52bd0904e54/genes-11-00230-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/238a3de5c8e1/genes-11-00230-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/09def9ec6f97/genes-11-00230-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/1f10538bfaa3/genes-11-00230-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/ebf756ad6c70/genes-11-00230-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/2c49ee30a615/genes-11-00230-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/c52bd0904e54/genes-11-00230-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/238a3de5c8e1/genes-11-00230-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/09def9ec6f97/genes-11-00230-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/1f10538bfaa3/genes-11-00230-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ebf0/7074254/ebf756ad6c70/genes-11-00230-g006.jpg

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