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一种抗胶质母细胞瘤的金（I）-氮杂环卡宾配合物会扭曲线粒体形态和生物能量学，从而抑制肿瘤生长。

An anti-glioblastoma gold(i)-NHC complex distorts mitochondrial morphology and bioenergetics to induce tumor growth inhibition.

作者信息

Greif Charles E, Mertens R Tyler, Berger Gilles, Parkin Sean, Awuah Samuel G

机构信息

Department of Chemistry, University of Kentucky Lexington Kentucky 40506 USA

Harvey Cushing Neuro-Oncology Laboratories, Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School Boston MA 02115 USA.

出版信息

RSC Chem Biol. 2023 May 25;4(8):592-599. doi: 10.1039/d3cb00051f. eCollection 2023 Aug 3.

DOI:10.1039/d3cb00051f
PMID:37547458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10398352/
Abstract

Glioblastoma multiforme (GBM) is the most lethal brain cancer subtype, often advanced by the time of initial diagnosis. Existing treatment modalities including surgery, chemotherapy and radiation have been stymied by recurrence, metastasis, drug resistance and brain targetability. Here, we report a geometrically distinct Au(i) complex ligated by N^N-bidentate ligands and supported by a N-heterocyclic ligand that modulates mitochondrial morphology to inhibit GBM and . This work benefits from the facile preparation of anti-GBM Au(i)-NHC complexes.

摘要

多形性胶质母细胞瘤（GBM）是最致命的脑癌亚型，在初次诊断时通常已处于晚期。包括手术、化疗和放疗在内的现有治疗方式一直受到复发、转移、耐药性和脑靶向性的阻碍。在此，我们报告了一种几何结构独特的金（I）配合物，它由N^N双齿配体连接，并由一个N-杂环配体支撑，该配体可调节线粒体形态以抑制GBM 。这项工作得益于抗GBM金（I）-氮杂环卡宾配合物的简便制备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/a4d37c05ae81/d3cb00051f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/e06984fd69b9/d3cb00051f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/227dc175761e/d3cb00051f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/76c6659218ef/d3cb00051f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/b5a16079e792/d3cb00051f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/a4d37c05ae81/d3cb00051f-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/e06984fd69b9/d3cb00051f-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/227dc175761e/d3cb00051f-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/76c6659218ef/d3cb00051f-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/b5a16079e792/d3cb00051f-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/171e/10398352/a4d37c05ae81/d3cb00051f-f4.jpg

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本文引用的文献

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Gold Complexes in Anticancer Therapy: From New Design Principles to Particle-Based Delivery Systems.抗癌治疗中的金配合物：从新设计原则到基于颗粒的递送系统。
Angew Chem Int Ed Engl. 2023 May 22;62(22):e202218000. doi: 10.1002/anie.202218000. Epub 2023 Mar 15.
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Mitochondria as a target of third row transition metal-based anticancer complexes.
线粒体作为第三排过渡金属抗癌配合物的靶标。
Curr Opin Chem Biol. 2023 Feb;72:102235. doi: 10.1016/j.cbpa.2022.102235. Epub 2022 Dec 12.
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Parvifloron D-based potential therapy for glioblastoma: Inducing apoptosis the mitochondria dependent pathway.基于小花素D的胶质母细胞瘤潜在疗法：诱导线粒体依赖途径的细胞凋亡。
Front Pharmacol. 2022 Oct 12;13:1006832. doi: 10.3389/fphar.2022.1006832. eCollection 2022.
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Organometallic gold(I) and gold(III) complexes for lung cancer treatment.用于肺癌治疗的有机金属金（I）和金（III）配合物。
Front Pharmacol. 2022 Sep 13;13:979951. doi: 10.3389/fphar.2022.979951. eCollection 2022.
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