Department of Biological Sciences, Dedman College of Humanities and Sciences, Southern Methodist University, Dallas, TX, 75275, USA.
Department of Neurosurgery, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA.
Neuromolecular Med. 2022 Mar;24(1):18-22. doi: 10.1007/s12017-021-08678-8. Epub 2021 Sep 6.
As a multi-functional cellular organelle, mitochondrial metabolic reprogramming is well recognized as a hallmark of cancer. The center of mitochondrial metabolism is oxidative phosphorylation (OXPHOS), in which cells use enzymes to oxidize nutrients, thereby converting the chemical energy to the biological energy currency ATPs. OXPHOS also creates the mitochondrial membrane potential and serve as the driving force of other mitochondrial metabolic pathways and experiences significant reshape in the different stages of tumor progression. In this minireview, we reviewed the major mitochondrial pathways that are connected to OXPHOS and are affected in cancer cells. In addition, we summarized the function of novel bio-active molecules targeting mitochondrial metabolic processes such as OXPHOS, mitochondrial membrane potential and mitochondrial dynamics. These molecules exhibit intriguing preclinical and clinical results and have been proven to be promising antitumor candidates in recent studies.
作为一种多功能的细胞细胞器，线粒体代谢重编程被认为是癌症的一个标志。线粒体代谢的中心是氧化磷酸化（OXPHOS），在此过程中，细胞利用酶来氧化营养物质，从而将化学能转化为生物能量货币 ATPs。OXPHOS 还产生线粒体膜电位，并作为其他线粒体代谢途径的驱动力，在肿瘤进展的不同阶段经历显著重塑。在这篇综述中，我们回顾了与 OXPHOS 相关并在癌细胞中受到影响的主要线粒体途径。此外，我们总结了靶向 OXPHOS、线粒体膜电位和线粒体动力学等线粒体代谢过程的新型生物活性分子的功能。这些分子在最近的研究中表现出有趣的临床前和临床结果，并已被证明是有前途的抗肿瘤候选物。
