Al-Quran Lina, Li Guang, Liu Zhezhang, Xiong Dan, Cao Xianwei, Xie Ting
Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang City, People's Republic of China.
Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang City, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Aug 1;16:1983-1996. doi: 10.2147/CCID.S419743. eCollection 2023.
Post-acne erythema (PAE) is one of the most common physical sequelae of acne regression, PAE can resolve spontaneously, but in some patients it may last for years. This study aimed to evaluate the efficacy and safety of narrow and broad spectrum filters of intense pulsed light (IPL) for the treatment of PAE.
This prospective study evaluated 60 patients with PAE for at least 6 months, assigned equally to three groups: 1st group received narrow-spectrum with vascular filter (530-650 nm and 900-1200 nm), 2nd group received broad-spectrum with (560/590-1200 nm) filters, the appropriate adjustments were made according to patient's skin colour. Every patient received four sessions one month apart. 3rd group is blank control group did not receive any treatment. CAT (CEA (Clinical Erythema Assessment), Area, and Telangiectasia) used to grade clearance of PAE before and after treatment, Investigators Global Assessment (IGA) used to assess the improvement score after the treatment, and Cardiff Acne Disability Index (CADI) used to evaluate the impact of PAE on patients' Quality of Life (QoL). Self-satisfaction scale completed at the follow-up. Adverse events and acne relapse were recorded.
A significant decrease of CAT score in vascular group (P<0.05). IGA scale showed significant improvement after vascular treatment. A significant decrease in CADI (P<0.05) after vascular treatment. Patient satisfaction was higher in vascular group than control and blank control groups. Acne relapse observed in control and blank control groups (40% and 15%, respectively).10% of patients showed pigmentation, 15% had blisters after 590 nm treatment.
IPL vascular filter (530-650 nm and 900-1200 nm) have efficacy in the treatment of PAE. CADI score, patient satisfaction, and acne relapse were significantly better after vascular narrow spectrum treatment than broad-spectrum treatment.
痤疮后红斑(PAE)是痤疮消退后最常见的身体后遗症之一,PAE可自发消退,但在一些患者中可能持续数年。本研究旨在评估强脉冲光(IPL)的窄谱和宽谱滤光片治疗PAE的疗效和安全性。
这项前瞻性研究评估了60例患有PAE至少6个月的患者,将其平均分为三组:第一组接受带血管滤光片的窄谱光(530 - 650纳米和900 - 1200纳米),第二组接受带(560/590 - 1200纳米)滤光片的宽谱光,根据患者肤色进行适当调整。每位患者每月接受一次,共四次治疗。第三组为空白对照组,未接受任何治疗。使用CAT(临床红斑评估(CEA)、面积和毛细血管扩张)对治疗前后PAE的清除情况进行分级,使用研究者整体评估(IGA)评估治疗后的改善评分,使用加的夫痤疮残疾指数(CADI)评估PAE对患者生活质量(QoL)的影响。在随访时完成自我满意度量表。记录不良事件和痤疮复发情况。
血管组的CAT评分显著降低(P<0.05)。血管治疗后IGA量表显示有显著改善。血管治疗后CADI显著降低(P<0.05)。血管组患者的满意度高于对照组和空白对照组。在对照组和空白对照组观察到痤疮复发(分别为40%和15%)。10%的患者出现色素沉着,590纳米治疗后15%的患者出现水疱。
IPL血管滤光片(530 - 650纳米和900 - 1200纳米)对PAE有治疗效果。血管窄谱治疗后的CADI评分、患者满意度和痤疮复发情况明显优于宽谱治疗。