Hong Ji Yeon, Seok Joon, Han Hye Sung, Park Kui Young
Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2025 Mar 10;40(9):e118. doi: 10.3346/jkms.2025.40.e118.
Acne is a chronic inflammatory condition affecting the sebaceous glands, with approximately 80% of individuals experiencing it at some point in their lives. Among adolescents, the incidence is reported to exceed 85%. The disease can significantly impact both physical and emotional aspects of a person's quality of life, leading to permanent scarring, poor self-image, depression, and anxiety. The standard first-line treatment for acne vulgaris includes conventional pharmacological approaches such as keratolytics, topical or oral antibiotics, retinoids, and hormonal agents. However, these treatments are not universally effective due to patient noncompliance, adverse drug effects, and the emergence of antibiotic resistance in , often resulting in high rates of recurrence. Consequently, non-pharmacological therapies have been developed as safe and effective alternatives or supplements to pharmacological treatment. These non-pharmacological approaches can serve as standalone treatment modalities, adjuncts to pharmacological therapy, or maintenance treatments. Current literature lacks comprehensive data on the classification of these non-pharmacological treatment options. This paper aims to provide a brief overview of recent research on the practical applications and potential mechanisms of non-pharmacological therapies for both acne and acne scars. Through elucidating the distinct mechanisms and therapeutic roles of these treatments, we aim to assist dermatologists and other healthcare providers in formulating more effective disease management strategies, thereby encouraging further research in this area.
痤疮是一种影响皮脂腺的慢性炎症性疾病，约80%的人在其生命中的某个阶段会经历此病。据报道，青少年中的发病率超过85%。该疾病会对一个人的生活质量的身体和情感方面产生重大影响，导致永久性疤痕、自我形象不佳、抑郁和焦虑。寻常痤疮的标准一线治疗包括传统药理学方法，如角质剥脱剂、外用或口服抗生素、维甲酸和激素类药物。然而，由于患者不依从、药物不良反应以及痤疮丙酸杆菌中抗生素耐药性的出现，这些治疗并非普遍有效，常常导致高复发率。因此，非药物疗法已被开发出来，作为药理学治疗的安全有效替代方法或补充方法。这些非药物方法可以作为独立的治疗方式、药理学治疗的辅助手段或维持治疗。目前的文献缺乏关于这些非药物治疗选择分类的全面数据。本文旨在简要概述近期关于痤疮和痤疮疤痕非药物疗法的实际应用和潜在机制的研究。通过阐明这些治疗的独特机制和治疗作用，我们旨在帮助皮肤科医生和其他医疗服务提供者制定更有效的疾病管理策略，从而鼓励在该领域进行进一步研究。
