阿曲库铵对心血管疾病患者的循环系统影响。
Circulatory effects of atracurium in patients with cardiovascular disease.
作者信息
Moyers J R, Carter J G, Fehr B L, Lineberry C C, Sokoll M D, Shimosato S
出版信息
Br J Anaesth. 1986;58 Suppl 1:83S-88S. doi: 10.1093/bja/58.suppl_1.83s.
PMID:3754759
Abstract
Atracurium 0.4 mg kg-1, which was sufficient to produce neuromuscular blockade sufficient for intubation, was administered as divided bolus doses to 40 patients with severe cardiovascular disease. Little haemodynamic change occurred. A transient reduction in arterial pressure was noted in one patient. Atracurium was found to be safe and effective, and administration in small bolus doses separated by 30 s may reduce the likelihood of significant circulatory changes.
摘要
将0.4毫克/千克的阿曲库铵以分次推注的方式给予40例重症心血管疾病患者，该剂量足以产生插管所需的神经肌肉阻滞。血流动力学变化很小。有1例患者出现动脉压短暂下降。结果发现阿曲库铵安全有效，以30秒的间隔给予小剂量推注可能会降低出现显著循环变化的可能性。
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