Zou Zhi-Li, Qiu Jian, Zhou Xiao-Bo, Huang Yu-Lan, Wang Jin-Yu, Zhou Bo, Zhang Yuan
Sichuan Provincial Center for Mental Health, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610000, Sichuan Province, China.
Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China.
World J Psychiatry. 2023 Jul 19;13(7):435-443. doi: 10.5498/wjp.v13.i7.435.
Genetic factors play an important role in the pathogenesis of panic disorder (PD). However, the effect of genetic variants on PD remains controversial.
To evaluate the associations between gene polymorphisms and PD risk and assess the effect of gene polymorphisms on the severity of clinical symptoms in PD.
We recruited 230 PD patients and 224 healthy controls in this study. All participants were assessed for anxiety and panic symptom severity using the Hamilton Anxiety Rating Scale (HAM-A) and Panic Disorder Severity Scale (PDSS). gene polymorphisms (rs1978340 and rs3749034) were genotyped and assessed for allele frequencies.
There were no significant differences between cases and controls in the genotype distributions or allele frequencies of (rs1978340 and rs3749034). In addition, the effect of (rs1978340 and rs3749034) on PD severity was not significant. However, regarding respiratory symptoms, patients with the rs1978340 A/A genotype had significantly higher scores than those with the A/G or G/G genotype.
Here, we showed that the A/A genotype of rs1978340 was associated with increased severity of respiratory symptoms in patients with PD.
遗传因素在惊恐障碍（PD）的发病机制中起重要作用。然而，基因变异对PD的影响仍存在争议。
评估基因多态性与PD风险之间的关联，并评估基因多态性对PD临床症状严重程度的影响。
本研究招募了230例PD患者和224名健康对照。使用汉密尔顿焦虑量表（HAM-A）和惊恐障碍严重程度量表（PDSS）对所有参与者的焦虑和惊恐症状严重程度进行评估。对基因多态性（rs1978340和rs3749034）进行基因分型并评估等位基因频率。
病例组和对照组在（rs1978340和rs3749034）的基因型分布或等位基因频率上没有显著差异。此外，（rs1978340和rs3749034）对PD严重程度的影响不显著。然而，关于呼吸系统症状，rs1978340 A/A基因型的患者得分显著高于A/G或G/G基因型的患者。
在此，我们表明rs1978340的A/A基因型与PD患者呼吸系统症状严重程度增加有关。
