Bläckberg Anna, Jönsson Astrid, Svensson Emma, Sunnerhagen Torgny, Kiasat Ali, Ljungquist Oskar
Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden.
Department of Infectious Diseases, Skåne University Hospital, Lund, Sweden.
Open Forum Infect Dis. 2023 Jul 11;10(8):ofad352. doi: 10.1093/ofid/ofad352. eCollection 2023 Aug.
Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in southern Sweden.
We conducted a population-based observational study comprising all episodes of PLA that occurred between 2011 and 2020 in the county of Skåne, southern Sweden. The primary outcome was defined as all-cause 90-day mortality and the secondary outcome was defined as the occurrence of a subsequent PLA.
A total of 452 episodes of PLA occurred in 360 patients during the study period. The 90-day mortality rate was 16% (n = 58) and the subsequent PLA rate was 20% (n = 92). In a multivariable logistic regression model, female sex (odds ratio [OR], 2.0 [95% confidence interval {CI}, 1.1-3.9]), malignancy (OR, 3.7 [95% CI, 1.9-7.1]), liver failure (OR, 6.3 [95% CI, 2.7-14.5]), and polymicrobial findings (OR, 3.8 [95% CI, 2.2-6.9]) were associated with death within 90 days ( < .05). Male sex (OR, 2.1 [95% CI, 1.2-3.6]), malignancy (OR, 2.1 [95% CI, 1.3-3.6]), age (64-74 years: OR, 2.5 [95% CI, 1.3-4.8]), and chronic liver disease (OR, 3.0 [95% CI, 1.4-6.5]) were associated with the risk of subsequent PLA ( ≤ .01).
Identifying different clinical variables associated with an unfavorable outcome may improve the management and treatment of patients with PLA and thus prevent the risk of death and subsequent PLA.
化脓性肝脓肿（PLA）是一种罕见疾病，与较高的死亡率和发病率相关。我们的目的是调查瑞典南部诊断为PLA的患者中与死亡率及后续PLA相关的变量。
我们进行了一项基于人群的观察性研究，纳入了2011年至2020年期间瑞典南部斯科讷县发生的所有PLA病例。主要结局定义为全因90天死亡率，次要结局定义为后续PLA的发生。
在研究期间，360例患者共发生452次PLA发作。90天死亡率为16%（n = 58），后续PLA发生率为20%（n = 92）。在多变量逻辑回归模型中，女性（比值比[OR]，2.0[95%置信区间{CI}，1.1 - 3.9]）、恶性肿瘤（OR，3.7[95% CI，1.9 - 7.1]）、肝衰竭（OR，6.3[95% CI，2.7 - 14.5]）和多微生物感染（OR，3.8[95% CI，2.2 - 6.9]）与90天内死亡相关（P <.05）。男性（OR，2.1[95% CI，1.2 - 3.6]）、恶性肿瘤（OR，2.1[95% CI，1.3 - 3.6]）、年龄（64 - 74岁：OR，2.5[95% CI，1.3 - 4.8]）和慢性肝病（OR，3.0[
