Fan Ziwen, Mei Mu, Chen Cen
Department of Respiratory Medicine, Changde Hospital, Xiangya School of Medicine, Central South University (The First people's Hospital of Changde City), Changde, China.
Front Med (Lausanne). 2025 Feb 13;12:1486256. doi: 10.3389/fmed.2025.1486256. eCollection 2025.
Anaerobic bacterial communities in the digestive tract play an important role in digestive tract infections and aspiration pneumonia. However, ectopic infections originating from these communities are uncommon.
We present a rare case of a 64-year-old immunocompetent female was admitted with no significant medical history who developed a pyogenic liver abscess and sepsis caused by multiple anaerobic bacteria of digestive tract origin. Metagenomic next-generation sequencing (mNGS) detected four types of anaerobic bacteria in both peripheral blood and abscess puncture fluid. Culture confirmed the presence of three of these microorganisms. Treatment with a combination of meropenem and metronidazole resulted in the patient's subsequent recovery and discharge.
This report highlights the occurrence of ectopic infections caused by multiple anaerobic bacteria leading to pyogenic liver abscess and sepsis, underscoring the importance of considering anaerobic bacteria and conducting rapid comprehensive pathogen detection in clinical practice.
消化道中的厌氧细菌群落对消化道感染和吸入性肺炎起着重要作用。然而，源自这些群落的异位感染并不常见。
我们报告一例罕见病例，一名64岁免疫功能正常的女性，既往无重大病史，因消化道来源的多种厌氧细菌导致化脓性肝脓肿和败血症入院。宏基因组下一代测序（mNGS）在外周血和脓肿穿刺液中检测到四种厌氧细菌。培养证实其中三种微生物存在。美罗培南和甲硝唑联合治疗使患者随后康复并出院。
本报告强调了由多种厌氧细菌引起的异位感染导致化脓性肝脓肿和败血症的发生，强调了在临床实践中考虑厌氧细菌并进行快速全面病原体检测的重要性。
