Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
University of Science and Technology of China, Hefei, Anhui, 230026, P. R. China.
Angew Chem Int Ed Engl. 2023 Dec 4;62(49):e202308396. doi: 10.1002/anie.202308396. Epub 2023 Aug 28.
Bioorthogonal chemistry is a promising toolbox for dissecting biological processes in the native environment. Recently, bioorthogonal reactions have attracted considerable attention in the medical field for treating diseases, since this approach may lead to improved drug efficacy and reduced side effects via in situ drug synthesis. For precise biomedical applications, it is a prerequisite that the reactions should occur in the right locations and on the appropriate therapeutic targets. In this minireview, we highlight the design and development of targeted bioorthogonal reactions for precise medical treatment. First, we compile recent strategies for achieving target-specific bioorthogonal reactions. Further, we emphasize their application for the precise treatment of different therapeutic targets. Finally, a perspective is provided on the challenges and future directions of this emerging field for safe, efficient, and translatable disease treatment.
生物正交化学是一种用于在天然环境中剖析生物过程的有前途的工具包。最近，生物正交反应在医学领域引起了相当大的关注，因为这种方法可以通过原位药物合成提高药物疗效和降低副作用。对于精确的生物医学应用，反应应该在正确的位置和适当的治疗靶点上发生是一个前提条件。在这篇小综述中，我们强调了设计和开发针对特定治疗靶点的生物正交反应的重要性。首先，我们总结了实现靶向生物正交反应的最新策略。此外，我们强调了它们在精确治疗不同治疗靶点中的应用。最后，我们对这个新兴领域在安全、高效和可转化疾病治疗方面的挑战和未来方向进行了展望。
