Zhou Yongwen, Yue Tong, Ding Yu, Tan Huiling, Weng Jianping, Luo Sihui, Zheng Xueying
Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2024 Jan-Feb;16(1):e1919. doi: 10.1002/wnan.1919. Epub 2023 Aug 7.
Atherosclerosis is a systemic pathophysiological condition contributing to the development of majority of polyvascular diseases. Nanomedicine is a novel and rapidly developing science. Due to their small size, nanoparticles are freely transported in vasculature, and have been widely employed as tools in analytical imaging techniques. Furthermore, the application of nanoparticles also allows target intervention, such as drug delivery and tissue engineering regenerative methods, in the management of major vascular diseases. Therefore, by summarizing the physical and chemical characteristics of common nanoparticles used in diagnosis and treatment of vascular diseases, we discuss the details of these applications from cellular, molecular, and in vivo perspectives in this review. Furthermore, we also summarize the status and challenges of the application of nanoparticles in clinical translation. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease Implantable Materials and Surgical Technologies > Nanomaterials and Implants Therapeutic Approaches and Drug Discovery > Emerging Technologies.
动脉粥样硬化是一种全身性病理生理状况，是导致大多数多血管疾病发生的原因。纳米医学是一门新兴且发展迅速的科学。由于纳米颗粒尺寸小，它们可在脉管系统中自由运输，并已被广泛用作分析成像技术的工具。此外，纳米颗粒的应用还使得在主要血管疾病的管理中能够进行靶向干预，如药物递送和组织工程再生方法。因此，通过总结用于诊断和治疗血管疾病的常见纳米颗粒的物理和化学特性，我们在本综述中从细胞、分子和体内角度讨论了这些应用的细节。此外，我们还总结了纳米颗粒在临床转化应用中的现状和挑战。本文分类如下：治疗方法与药物发现>心血管疾病的纳米医学；可植入材料与手术技术>纳米材料与植入物；治疗方法与药物发现>新兴技术。
