Department of Dental, North China University of Science and Technology Affiliated Hospital, Tangshan, Hebei, China.
Tangshan Second Hospital, Tangshan, Hebei, China.
Pak J Pharm Sci. 2023 Mar;36(2(Special)):631-638.
This study is to evaluate the effect of receptor for activated c kinase 1 (RACK1) and peripheral blood M2/M1 monocytes ratio on the prognosis of patients with oral squamous cell carcinoma (OSCC). A total of 115 OSCC patients who underwent radical surgery in North China University of Science and Technology Affiliated Hospital from January 2015 to December 2015 were included in the experimental group and 34 healthy individuals after a physical examination during the same period were included in the control group. Cancer and para-cancerous tissues were collected and the relationship between RACK1 and M2/M1 ratio and the prognosis of OSCC patients and its predictive value were analyzed. RACK1, M2/M1 ratio, clinical stages, lymphatic metastasis, recurrence and metastasis were considered independent factors for the prognosis of OSCC patients (p<0.05); In addition, RACK1 and the M2/M1 ratio were proven to be of significant predictive values for the prognosis of OSCC patients (p<0.05). RACK1 and peripheral blood M2/M1 monocytes ratio demonstrate great potential as prognostic predictors of OSCC patients.
本研究旨在评估激活蛋白激酶 C 受体 1（RACK1）和外周血 M2/M1 单核细胞比值对口腔鳞状细胞癌（OSCC）患者预后的影响。选取 2015 年 1 月至 12 月于华北理工大学附属医院行根治性手术的 115 例 OSCC 患者为实验组，同期体检的 34 例健康者为对照组。取癌及癌旁组织，分析 RACK1 与 M2/M1 比值与 OSCC 患者预后的关系及其预测价值。RACK1、M2/M1 比值、临床分期、淋巴转移、复发转移均为 OSCC 患者预后的独立影响因素（p<0.05）；此外，RACK1 及 M2/M1 比值对 OSCC 患者预后均有显著预测价值（p<0.05）。RACK1 及外周血 M2/M1 单核细胞比值有望成为 OSCC 患者的预后预测指标。
