Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
Biomater Sci. 2023 Sep 12;11(18):6149-6159. doi: 10.1039/d3bm01101a.
Controlled drug release of nanoparticles was achieved by irreversibly disrupting polymer micelles through high-intensity focused ultrasound (HIFU) induction. An ultrasound-responsive block copolymer was synthesized, comprising an end-functional Eosin Y fluorophore, 2-tetrahydropyranyl acrylate (THPA), and acrylate mannose (MAN). The block copolymer was then self-assembled to produce micelles. The chemotherapy drug dasatinib (DAS) and the sonodynamic therapy agent methylene blue (MB) were encapsulated by the self-assembly of the block copolymer. This targeted nanoparticle enables sonodynamic therapy through high-intensity focused ultrasound while triggering nanoparticle disassembly for controlled drug release. The ultrasound-mediated, non-invasive strategy provides external spatiotemporal control for targeted tumour treatment.
通过高强度聚焦超声（HIFU）诱导不可逆地破坏聚合物胶束来实现纳米颗粒的控释。合成了一种超声响应的嵌段共聚物，包含端基功能化的曙红荧光团、2-四氢吡喃丙烯酸酯（THPA）和丙烯酰甘露糖（MAN）。然后，嵌段共聚物自组装形成胶束。将化疗药物达沙替尼（DAS）和声动力学治疗剂亚甲蓝（MB）包封在嵌段共聚物的自组装中。这种靶向纳米颗粒通过高强度聚焦超声实现声动力学治疗，同时触发纳米颗粒解组装以实现控释药物释放。超声介导的非侵入性策略为靶向肿瘤治疗提供了外部时空控制。
