Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, China.
School of Public Health of Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, China.
Eur J Nutr. 2023 Dec;62(8):3207-3216. doi: 10.1007/s00394-023-03225-6. Epub 2023 Aug 7.
Skeletal muscle strength decline is strongly associated with inflammation. While previous research has confirmed that diet can modulate chronic inflammation, little is known about the relationship between an anti-inflammatory dietary pattern and muscle strength. The aim of this study was to investigate the association between an anti-inflammatory dietary pattern and handgrip strength decline in a large-scale adult population.
During a median follow-up period of 3 years, this prospective cohort study was carried out between 2013 and 2018 and included 2840 participants (60.2% men). Dietary intake was assessed using a validated food frequency questionnaire at baseline, and handgrip strength was measured annually with a handheld digital dynamometer. The dietary inflammatory potential score was calculated using white blood cell count and hypersensitive C-reactive protein as inflammatory markers, and was determined using reduced rank regression and stepwise linear regression. Multivariable linear regression models were used to estimate the association between the dietary inflammatory potential score and the annualized change in handgrip strength and weight-adjusted handgrip strength.
After adjusting for multiple confounding factors, significant associations between the dietary inflammatory potential score and the annualized change in handgrip strength and weight-adjusted handgrip strength in women, with values of - 0.8322 kg (95% confidence interval [CI] - 1.6405, - 0.0238; P < 0.0408) and - 0.0171 kg/kg (95% CI - 0.0310, - 0.0032; P < 0.0158), respectively. However, no significant differences were observed between the dietary inflammatory potential score and the annualized change in handgrip strength and weight-adjusted handgrip strength in men, with values of 0.1578 kg (95% CI - 0.6107, 0.9261; P < 0.6874) and - 0.0014 kg/kg (95% CI - 0.0115, 0.0088; P < 0.7933), respectively.
Our findings suggest that consuming an anti-inflammatory dietary pattern could be a protective strategy against the decline in skeletal muscle strength in women.
骨骼肌力量下降与炎症密切相关。虽然之前的研究已经证实饮食可以调节慢性炎症，但对于抗炎饮食模式与肌肉力量之间的关系知之甚少。本研究旨在调查在大规模成人人群中，抗炎饮食模式与握力下降之间的关系。
在 2013 年至 2018 年期间进行的这项前瞻性队列研究中，在中位随访 3 年后，共纳入了 2840 名参与者（60.2%为男性）。在基线时使用经过验证的食物频率问卷评估饮食摄入情况，每年使用手持式数字测力计测量握力。使用白细胞计数和超敏 C 反应蛋白作为炎症标志物，通过降秩回归和逐步线性回归计算饮食炎症潜在评分。使用多变量线性回归模型来估计饮食炎症潜在评分与握力和体重校正握力的年度变化之间的关联。
在校正了多种混杂因素后，在女性中，饮食炎症潜在评分与握力和体重校正握力的年度变化之间存在显著关联，其值分别为-0.8322kg（95%置信区间 [CI] -1.6405，-0.0238；P<0.0408）和-0.0171kg/kg（95% CI -0.0310，-0.0032；P<0.0158）。然而，在男性中，饮食炎症潜在评分与握力和体重校正握力的年度变化之间没有显著差异，其值分别为 0.1578kg（95% CI -0.6107，0.9261；P<0.6874）和-0.0014kg/kg（95% CI -0.0115，0.0088；P<0.7933）。
我们的研究结果表明，摄入抗炎饮食模式可能是女性骨骼肌力量下降的一种保护策略。
