Department of Otolaryngology, Hospital Universitario Ramón Y Cajal, Ctra. Colmenar Km 9.100, 28034, Madrid, Spain.
Eur Arch Otorhinolaryngol. 2024 Feb;281(2):737-742. doi: 10.1007/s00405-023-08178-4. Epub 2023 Aug 7.
The assessment of necrotizing external otitis requires a high index of suspicion by the attending physician. The purpose of the study is to determine the accuracy of parameters available at the Emergency Department for the diagnosis of this pathology.
Retrospective diagnostic accuracy study. Patients consulting at the Emergency Department for longstanding ear swelling, severe otalgia, and failure to respond to topical treatment were included. Otoscopy, physical examination, CT appearance, and analytical results were tested for the diagnosis of necrotizing external otitis, using nuclear imaging as gold standard. Sensitivity, specificity, likelihood ratios and ROC curves were calculated.
24 patients were included; 13 cases were necrotizing external otitis, and 11 cases were other external ear pathologies. Erythrocyte sedimentation rate and C-reactive protein levels were significantly associated with necrotizing external otitis (AUC 0.92 p < 0.001, and 0.8 p < 0.001). Positive likelihood ratios were 10.15 for values of erythrocyte sedimentation rate over 26 mm/h, and 8.25 for C-reactive protein levels over 10 mg/L. Negative likelihood ratios were 0.08 and 0.28, respectively. These results were significant. The rest of clinical and radiological parameters were less accurate.
Erythrocyte sedimentation rate and C-reactive protein are useful parameters in the evaluation of a case of longstanding otitis with clinical suspicion of necrotizing external otitis. If any of them is elevated, the probability of suffering this condition is significantly increased. If they are within normal ranges, an alternative diagnosis should be sought.
坏死性外耳道炎的评估需要主治医生有很高的怀疑指数。本研究的目的是确定急诊科现有的参数对该病理诊断的准确性。
回顾性诊断准确性研究。纳入在急诊科就诊的长期耳肿胀、剧烈耳痛和对外用治疗无反应的患者。使用核成像作为金标准,对耳镜检查、体格检查、CT 表现和分析结果进行检测,以诊断坏死性外耳道炎。计算了灵敏度、特异性、似然比和 ROC 曲线。
共纳入 24 例患者;13 例为坏死性外耳道炎,11 例为其他外耳疾病。红细胞沉降率和 C 反应蛋白水平与坏死性外耳道炎显著相关(AUC 0.92 p<0.001 和 0.8 p<0.001)。红细胞沉降率>26mm/h 和 C 反应蛋白水平>10mg/L 的阳性似然比分别为 10.15 和 8.25。阴性似然比分别为 0.08 和 0.28,结果均有统计学意义。其余临床和影像学参数准确性较低。
红细胞沉降率和 C 反应蛋白是评估具有临床怀疑坏死性外耳道炎的长期耳炎的有用参数。如果其中任何一项升高,则患该病的可能性显著增加。如果在正常范围内,则应寻求其他诊断。