Fujii H, Kashiwadani M, Maekawa T, Suyama Y, Iwai M, Miyoshi M, Urata Y
Gan No Rinsho. 1986 Apr;32(4):413-20.
Reports of the presence of two histologically different neoplasms in one organ are still unusual. We experienced a rare case of coexisting primary malignant lymphoma and adenocarcinoma of the stomach. A 66-year-old woman was admitted in April 1983 because of weight loss and epigastralgia. Several examinations including gallium scan, upper GI endoscopy, biopsy and touch cytology of the stomach, were performed, and she was diagnosed as having primary malignant lymphoma (noncleaved, large cell type) of the stomach. After the administration of 20 mg of vincristine, 6,000 mg of cyclophosphamide, 1,000 mg of prednisolone and 150 mg of Adriamycin, she improved to complete remission in August 1983. In February 1984, she received gastrectomy because of stenosis of the esophagogastric junction. Microscopic examination of the ulcerated lesion at esophagogastric junction revealed moderately differentiated tubular adenocarcinoma infiltrating to the subserosa. Despite chemotherapy, peritonitis carcinomatosa developed, and the patient died of cachexia in July 1984.
关于一个器官中存在两种组织学上不同的肿瘤的报道仍然不常见。我们遇到了一例罕见的胃原发性恶性淋巴瘤与腺癌共存的病例。一名66岁女性于1983年4月因体重减轻和上腹部疼痛入院。进行了包括镓扫描、上消化道内镜检查、胃活检和触摸细胞学检查在内的多项检查，她被诊断为胃原发性恶性淋巴瘤（非裂细胞、大细胞型）。在给予20毫克长春新碱、6000毫克环磷酰胺、1000毫克泼尼松龙和150毫克阿霉素后，她于1983年8月病情改善至完全缓解。1984年2月，她因食管胃交界处狭窄接受了胃切除术。食管胃交界处溃疡病变的显微镜检查显示为中分化管状腺癌，浸润至浆膜下层。尽管进行了化疗，但仍发生了癌性腹膜炎，患者于1984年7月死于恶病质。
