John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.
John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Robinson Way, Cambridge, CB2 0PY, UK.
J Neuroimmunol. 2023 Sep 15;382:578154. doi: 10.1016/j.jneuroim.2023.578154. Epub 2023 Jul 24.
Immune dysregulation is heavily implicated in Parkinson's disease (PD) but the role of Natural Killer (NK) cells has not been well characterised. Accumulating evidence indicates the immune response peaks early in the disease, hence this study focused on characterising NK cells in recently diagnosed PD. PBMCs were obtained from PD cases (< 2 years duration) and age-matched controls and immunophenotyped using flow cytometry. We found an increased proportion and number of NK cells (CD3-CD56+), mature cytotoxic NK cells (CD3-CD16 + CD56dim), and NK cells expressing the activation marker, NKG2D. This implies NK cells are activated in the earliest stages of PD.
免疫失调在帕金森病（PD）中起着重要作用，但自然杀伤（NK）细胞的作用尚未得到很好的描述。越来越多的证据表明，免疫反应在疾病早期达到高峰，因此本研究集中于对近期诊断为 PD 的 NK 细胞进行特征描述。我们从 PD 病例（<2 年病程）和年龄匹配的对照组中获得 PBMCs，并使用流式细胞术进行免疫表型分析。结果发现 NK 细胞（CD3-CD56+）、成熟细胞毒性 NK 细胞（CD3-CD16+CD56dim）和表达激活标志物 NKG2D 的 NK 细胞的比例和数量增加。这意味着 NK 细胞在 PD 的最早阶段被激活。
