Chen Jitao, Ye Penghui, Gu Rifang, Zhu Huan, He Wenjie, Mu Xingrui, Wu Xingqian, Pang Huiwen, Han Felicity, Nie Xuqiang
College of Pharmacy, Zunyi Medical University, Zunyi 563000, China; Key Lab of the Basic Pharmacology of the Ministry of Education & Joint International Research Laboratory of Ethnomedicine of Chinese Ministry of Education, Zunyi Medical University, Zunyi 563000, China.
University Medical Office, Zunyi Medical University, Zunyi 563000, China.
Biochem Pharmacol. 2023 Sep;215:115736. doi: 10.1016/j.bcp.2023.115736. Epub 2023 Aug 5.
In the past, neuropeptide substance P (SP) was predominantly recognized as a neuroinflammatory factor, while its potent healing activity was overlooked. This paper aims to review the regulatory characteristics of neuropeptide SP in both normal and diabetic wound healing. SP actively in the regulation of wound healing-related cells directly and indirectly, exhibiting robust inflammatory properties, promoting cell proliferation and migration and restoring the activity and paracrine ability of skin cells under diabetic conditions. Furthermore, SP not only regulates healing-related cells but also orchestrates the immune environment, thereby presenting unique and promising application prospects in wound intervention. As new SP-based preparations are being explored, SP-related drugs are poised to become an effective therapeutic intervention for diabetic foot ulcers (DFU).
过去，神经肽P物质（SP）主要被认为是一种神经炎症因子，而其强大的愈合活性却被忽视。本文旨在综述神经肽SP在正常和糖尿病伤口愈合中的调节特性。SP直接和间接地积极参与伤口愈合相关细胞的调节，表现出强大的炎症特性，促进细胞增殖和迁移，并在糖尿病条件下恢复皮肤细胞的活性和旁分泌能力。此外，SP不仅调节愈合相关细胞，还协调免疫环境，从而在伤口干预方面展现出独特且有前景的应用前景。随着基于SP的新制剂不断被探索，与SP相关的药物有望成为治疗糖尿病足溃疡（DFU）的有效治疗手段。
