Liu Qian, Liu Meng, Yang Tianshu, Wang Xinting, Cheng Peipei, Zhou Hua
Institute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Comprehensive treatment area of Traditional Chinese Medicine, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Mitochondrion. 2023 Sep;72:72-83. doi: 10.1016/j.mito.2023.08.001. Epub 2023 Aug 6.
Mitochondrial transplantation is a promising solution for the heart following ischemia-reperfusion injury due to its capacity to replace damaged mitochondria and restore cardiac function. However, many barriers (such as inadequate mitochondrial internalization, poor survival of transplanted mitochondria, few mitochondria colocalized with cardiac cells) compromise the replacement of injured mitochondria with transplanted mitochondria. Therefore, it is necessary to optimize mitochondrial transplantation therapy to improve clinical effectiveness. By analogy, myocardial ischemia-reperfusion injury is like a withered flower, it needs to absorb enough nutrients to recover and bloom. In this review, we present a comprehensive overview of "nutrients" (source of exogenous mitochondria and different techniques for mitochondrial isolation), "absorption" (mitochondrial transplantation approaches, mitochondrial transplantation dose and internalization mechanism), and "flowering" (the mechanism of mitochondrial transplantation in cardioprotection) for myocardial ischemia-reperfusion injury.
线粒体移植是解决心脏缺血再灌注损伤的一种有前景的方法，因为它有能力替代受损的线粒体并恢复心脏功能。然而，许多障碍（如线粒体内化不足、移植线粒体存活不佳、与心脏细胞共定位的线粒体数量少）影响了用移植线粒体替代受损线粒体的效果。因此，有必要优化线粒体移植疗法以提高临床疗效。打个比方，心肌缺血再灌注损伤就像一朵枯萎的花，它需要吸收足够的养分才能恢复并绽放。在这篇综述中，我们全面概述了针对心肌缺血再灌注损伤的“养分”（外源性线粒体的来源和线粒体分离的不同技术）、“吸收”（线粒体移植方法、线粒体移植剂量和内化机制）以及“开花”（线粒体移植在心脏保护中的机制）。
