Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, 515063, China; Institute of Marine Sciences, Shantou University, Shantou, 515063, China.
Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, 515063, China; Institute of Marine Sciences, Shantou University, Shantou, 515063, China.
Fish Shellfish Immunol. 2023 Sep;140:108984. doi: 10.1016/j.fsi.2023.108984. Epub 2023 Aug 5.
Innate immunity plays the most important system responsible for protecting crustaceans against invading pathogens. White spot syndrome virus (WSSV) is considered a serious pathogen in crustaceans with high cumulative mortality and morbidity in infected animals. Understanding the mechanism of the response of hosts to WSSV infection is necessary, which is useful for effective prevention in controlling infection. In this review, we summarize the participation of signaling pathways (toll, immune deficiency, JAK/STAT, endocytosis, mitogen-activated protein kinase, PI3K/Akt/mTOR, cGAS-STING, Wingless/Integrated signal transduction, and prophenoloxidase (proPO) cascade) and the activity of cells (apoptosis, autophagy, as well as, reactive oxygen species and antioxidant enzymes) in the cellular-mediated immune response of crustaceans during WSSV infection. The information presented in this current review is important for a better understanding of the mechanism of the response of hosts to pathogens. Additionally, this provides a piece of basic knowledge for discovering approaches to strengthen the immune system and resistance of cultured animals against viral infections.
先天免疫是甲壳动物抵御入侵病原体最重要的系统。白斑综合征病毒 (WSSV) 被认为是甲壳动物的一种严重病原体，感染动物的累积死亡率和发病率都很高。了解宿主对 WSSV 感染的反应机制对于有效预防和控制感染是必要的。在这篇综述中，我们总结了信号通路（ toll、免疫缺陷、JAK/STAT、内吞作用、丝裂原激活蛋白激酶、PI3K/Akt/mTOR、cGAS-STING、Wingless/Integrated 信号转导和酚氧化酶原 (proPO) 级联）和细胞（凋亡、自噬以及活性氧和抗氧化酶）在甲壳动物细胞介导的免疫反应中的参与，在 WSSV 感染过程中。本综述中提供的信息对于更好地理解宿主对病原体反应的机制非常重要。此外，这为发现增强养殖动物免疫系统和抗病毒感染能力的方法提供了基础知识。
