State Key Laboratory for Biocontrol / School of Marine Sciences, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Sun Yat-sen University, Guangzhou, PR China.
State Key Laboratory for Biocontrol / School of Marine Sciences, Sun Yat-sen University, Guangzhou, PR China; School of Life Sciences, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Sun Yat-sen University, Guangzhou, PR China.
Fish Shellfish Immunol. 2019 Jan;84:558-571. doi: 10.1016/j.fsi.2018.10.043. Epub 2018 Oct 22.
As invertebrates, shrimps rely on multiple innate defense reactions, including humoral immunity and cellular immunity to recognize and eliminate various invaders, such as viruses. White spot syndrome virus (WSSV) causes the most prevalent and devastating viral disease in penaeid shrimps, which are the most widely cultured species in the coastal waters worldwide. In the last couple of decades, studies about WSSV implicate a dual role of the immune system in protecting shrimps against the infection; these studies also explore on the pathogenesis of WSSV infection. Herein, we review our current knowledge of the innate immune responses of shrimps to WSSV, as well as the molecular mechanisms used by this virus to evade host immune responses or actively subvert them for its own benefit. Deciphering the interactions between WSSV and the shrimp host is paramount to understanding the mechanisms that regulate the balance between immune-mediated protection and pathogenesis during viral infection and to the development of a safe and effective WSSV defensive strategy.
虾类作为无脊椎动物，依赖多种先天防御反应，包括体液免疫和细胞免疫，来识别和清除各种入侵物，如病毒。白斑综合征病毒（WSSV）是对虾养殖中最常见和最具破坏性的病毒性疾病病原体，对虾是全球沿海水域养殖最广泛的虾类。在过去的几十年中，有关 WSSV 的研究表明免疫系统在保护虾类免受感染方面具有双重作用；这些研究还探讨了 WSSV 感染的发病机制。本文综述了虾类先天免疫系统对 WSSV 的反应，以及该病毒逃避宿主免疫反应或主动颠覆免疫反应以谋取自身利益的分子机制。解析 WSSV 与虾类宿主之间的相互作用对于理解在病毒感染过程中调节免疫介导的保护和发病机制之间平衡的机制以及开发安全有效的 WSSV 防御策略至关重要。
