Fang L J, Yao X D, Lu M Q, Chu B, Shi L, Gao S, Xiang Q Q, Wang Y T, Liu X, Ding Y H, Chen Y, Wang M Z, Zhao X, Hu W K, Sun K, Bao L
Department of Hematology, Beijing Jishuitan Hospital, Beijing 100096, China.
Zhonghua Xue Ye Xue Za Zhi. 2023 May 14;44(5):395-400. doi: 10.3760/cma.j.issn.0253-2727.2023.05.007.
To compare the predictive efficacy of the two thrombosis risk assessment scores (Padua and IMPEDE scores) in venous thromboembolism (VTE) within 6 months in patients with newly diagnosed multiple myeloma (NDMM) in China. This study reviewed the clinical data of 421 patients with NDMM hospitalized in Beijing Jishuitan Hospital from April 2014 to February 2022. The sensitivity, specificity, accuracy, and Youden index of the two scores were calculated to quantify the thrombus risk assessment of VTE by the Padua and IMPEDE scores. The receiver operating characteristics curves of the two evaluation scores were drawn. The incidence of VTE was 14.73%. The sensitivity, specificity, accuracy, and Youden index of the Padua score were 100%, 0%, 14.7%, and 0% and that of the IMPEDE score was 79%, 44%, 49.2%, and 23%, respectively. The areas under the curve of Padua and IMPEDE risk assessment scores were 0.591 and 0.722, respectively. IMPEDE score is suitable for predicting VTE within 6 months in patients with NDMM.
比较两种血栓形成风险评估评分（帕多瓦评分和IMPEDE评分）对中国新诊断多发性骨髓瘤（NDMM）患者6个月内静脉血栓栓塞症（VTE）的预测效能。本研究回顾了2014年4月至2022年2月在北京积水潭医院住院的421例NDMM患者的临床资料。计算两种评分的敏感性、特异性、准确性和尤登指数，以量化帕多瓦评分和IMPEDE评分对VTE的血栓风险评估。绘制两种评估评分的受试者工作特征曲线。VTE发生率为14.73%。帕多瓦评分的敏感性、特异性、准确性和尤登指数分别为100%、0%、14.7%和0%，IMPEDE评分的分别为79%、44%、49.2%和23%。帕多瓦和IMPEDE风险评估评分的曲线下面积分别为0.591和0.722。IMPEDE评分适用于预测NDMM患者6个月内的VTE。
