光疗：极低出生体重早产儿坏死性小肠结肠炎的新危险因素？一项回顾性病例对照研究。
Phototherapy: a new risk factor for necrotizing enterocolitis in very low birth weight preterm infants? a retrospective case-control study.
机构信息
Department of Pediatrics, Women and Children's Hospital of Chongqing Medical University/Chongqing Health Center for Women and Children, Chongqing, China.
出版信息
J Perinatol. 2023 Nov;43(11):1363-1367. doi: 10.1038/s41372-023-01744-y. Epub 2023 Aug 7.
OBJECTIVE
To investigate the association between phototherapy (PT) and the development of necrotizing enterocolitis (NEC) in very low birth weight (VLBW) infants.
STUDY DESIGN
A retrospective case-control study was conducted on VLBW infants with or without NEC (stage IIA or greater) born at ≤35 weeks' gestation in a tertiary hospital over 7 years. Sample size calculation, trend test, as well as univariate and multiple logistic regression analyses were employed.
RESULTS
A total of 824 VLBW infants were reviewed, with 74 cases and 122 controls finally enrolled. The odds of NEC increased with the duration and number of PT sessions. Exposure to >120 h and >4 instances of PT were significantly associated with NEC in multivariate analysis.
CONCLUSION
This is the first study suggesting a potential association between PT and development of NEC in VLBW infants. This association needs further exploration.
目的
探讨光疗（PT）与极低出生体重儿（VLBW）坏死性小肠结肠炎（NEC）发展之间的关系。
研究设计
对 7 年间在一家三级医院出生、胎龄≤35 周的 VLBW 婴儿进行了一项伴有或不伴有 NEC（IIA 期或更高级别）的回顾性病例对照研究。采用样本量计算、趋势检验以及单变量和多变量逻辑回归分析。
结果
共回顾了 824 例 VLBW 婴儿，最终纳入了 74 例病例和 122 例对照。NEC 的发病风险随 PT 治疗时间和次数的增加而增加。多变量分析显示，暴露于>120 小时和>4 次 PT 与 NEC 显著相关。
结论
这是第一项表明光疗与 VLBW 婴儿 NEC 发展之间存在潜在关联的研究。这种关联需要进一步探讨。
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