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新生儿溶血病中坏死性小肠结肠炎发生的危险因素：一篇综述

Risk factors for the development of necrotizing enterocolitis in neonatal hemolytic disease: a mini review.

作者信息

Yu Haiyue, Guo Wanxu, Wang Yuan, Zhang Yunfeng

机构信息

Department of Neonatology, the Second Hospital of Jilin University, Changchun, Jilin, China.

出版信息

Front Pediatr. 2025 Jul 29;13:1639423. doi: 10.3389/fped.2025.1639423. eCollection 2025.

DOI:10.3389/fped.2025.1639423
PMID:40800598
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12339530/
Abstract

Hemolytic disease of the newborn (HDN) is a common disease of neonates, and necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder and both occur in the neonatal period that can significantly increase the risk of death in children. Cases of NEC associated with HDN are increasing. The purpose of this paper is to collect and present relevant research data to understand the risk factors associated with necrotizing enterocolitis in neonatal hemolytic disease, and to provide reasonable guidance and reference for clinical work.

摘要

新生儿溶血病（HDN）是新生儿的常见疾病，坏死性小肠结肠炎（NEC）是一种严重的胃肠道疾病，二者均发生于新生儿期，可显著增加儿童死亡风险。与HDN相关的NEC病例正在增加。本文旨在收集并呈现相关研究数据，以了解新生儿溶血病中与坏死性小肠结肠炎相关的危险因素，并为临床工作提供合理的指导与参考。

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Risk factors for the development of necrotizing enterocolitis in neonatal hemolytic disease: a mini review.新生儿溶血病中坏死性小肠结肠炎发生的危险因素：一篇综述
Front Pediatr. 2025 Jul 29;13:1639423. doi: 10.3389/fped.2025.1639423. eCollection 2025.
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本文引用的文献

1
Efficacy of single-and double-volume exchange transfusion for neonatal hyperbilirubinemia.单倍量和双倍量换血疗法治疗新生儿高胆红素血症的疗效
J Med Biochem. 2023 Aug 25;42(3):484-491. doi: 10.5937/jomb0-42668.
2
Association of anemia and platelet activation with necrotizing enterocolitis with or without sepsis among low birth weight neonates: a case-control study.低出生体重新生儿中贫血和血小板活化与坏死性小肠结肠炎伴或不伴败血症的关联：一项病例对照研究
Front Pediatr. 2023 Aug 31;11:1172042. doi: 10.3389/fped.2023.1172042. eCollection 2023.
3
Phototherapy: a new risk factor for necrotizing enterocolitis in very low birth weight preterm infants? a retrospective case-control study.光疗：极低出生体重早产儿坏死性小肠结肠炎的新危险因素？一项回顾性病例对照研究。
J Perinatol. 2023 Nov;43(11):1363-1367. doi: 10.1038/s41372-023-01744-y. Epub 2023 Aug 7.
4
[Interpretation of "International guidelines regarding the role of IVIG in the management of Rh- and ABO-mediated haemolytic disease of the newborn"].《关于静脉注射免疫球蛋白在新生儿 Rh 和 ABO 血型介导的溶血性疾病管理中作用的国际指南解读》
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Nov 15;24(11):1183-1188. doi: 10.7499/j.issn.1008-8830.2205158.
5
Analysis of the effect of phototherapy on intestinal probiotics and metabolism in newborns with jaundice.光疗对新生儿黄疸患儿肠道益生菌及代谢的影响分析
Front Pediatr. 2022 Oct 6;10:878473. doi: 10.3389/fped.2022.878473. eCollection 2022.
6
Necrotizing Enterocolitis.坏死性小肠结肠炎。
Clin Perinatol. 2021 Jun;48(2):229-250. doi: 10.1016/j.clp.2021.03.002.
7
Challenges of phototherapy for neonatal hyperbilirubinemia (Review).新生儿高胆红素血症光疗的挑战（综述）
Exp Ther Med. 2021 Mar;21(3):231. doi: 10.3892/etm.2021.9662. Epub 2021 Jan 20.
8
Effect of head covering on phototherapy induced hypocalcemia in term neonates with hyperbilirubinemia: A randomised controlled study.头部覆盖物对高胆红素血症足月新生儿光疗引起低钙血症的影响：一项随机对照研究。
J Neonatal Perinatal Med. 2021;14(2):245-251. doi: 10.3233/NPM-200442.
9
Challenges in diagnosing necrotizing enterocolitis.诊断坏死性小肠结肠炎的挑战。
Pediatr Res. 2020 Aug;88(Suppl 1):16-20. doi: 10.1038/s41390-020-1090-4.
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Vox Sang. 2020 Feb;115(2):196-201. doi: 10.1111/vox.12862. Epub 2019 Dec 19.