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一种罕见但侵袭性强的恶性肿瘤:胃肠道神经外胚层肿瘤(GNET)病例报告

A Rare but Aggressive Malignancy: A Case Report of a Gastrointestinal Neuroectodermal Tumor (GNET).

作者信息

Saeed Shahzeb, Grezenko Han, Nisar Lyba, Rehman Abdur, Riyaz Amina, Cook Daniel E, Kamran Muhammad

机构信息

Internal Medicine, Army Medical College, Islamabad, PAK.

Medicine, Guangxi Medical University, Nanning, CHN.

出版信息

Cureus. 2023 Jul 7;15(7):e41509. doi: 10.7759/cureus.41509. eCollection 2023 Jul.

Abstract

Gastrointestinal neuroectodermal tumors (GNETs) are extremely rare and intriguing malignancies originating from neural crest cells in the digestive tract. The digestive tract's neural crest cells can give rise to incredibly unusual and interesting gastrointestinal neuroectodermal tumors (GNETs). GNETs present considerable hurdles in diagnosis and management because of their rarity and varied expression. In this case report, a 45-year-old male patient is described who had signs of GNET, such as exhaustion, weight loss, and abdominal pain. A 7-cm jejunum tumor and related thickening of the gut wall were discovered using imaging investigations. The diagnosis of malignant GNET was confirmed by surgical resection, and adjuvant treatment was given. A recurring tumor required a second surgical procedure despite an initial disease-free period. The report emphasizes the difficulties involved in the diagnosis, treatment, and long-term effects of GNETs. The rarity of GNETs necessitates the development of standardized treatment protocols as well as additional research to enhance diagnostic precision and explore novel therapeutic approaches for this aggressive malignancy.

摘要

胃肠道神经外胚层肿瘤(GNETs)是起源于消化道神经嵴细胞的极其罕见且引人关注的恶性肿瘤。消化道的神经嵴细胞可引发极其罕见且有趣的胃肠道神经外胚层肿瘤(GNETs)。由于其罕见性和多样的表现,GNETs在诊断和治疗方面存在相当大的障碍。在本病例报告中,描述了一名45岁男性患者,他有GNETs的症状,如疲惫、体重减轻和腹痛。通过影像学检查发现了一个7厘米的空肠肿瘤以及相关的肠壁增厚。通过手术切除确诊为恶性GNET,并给予辅助治疗。尽管最初有一段无病期,但复发性肿瘤需要进行第二次手术。该报告强调了GNETs在诊断、治疗和长期影响方面所涉及的困难。GNETs的罕见性需要制定标准化的治疗方案以及开展更多研究,以提高诊断准确性并探索针对这种侵袭性恶性肿瘤的新治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09cc/10404388/bf7c59bcb9a5/cureus-0015-00000041509-i01.jpg

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