Ma Ziwen, Chu Liming, Zhang Yan, Lu Fang, Zhu Yun, Wu Fei, Zhang Zhiping
Department of Obstetrics and Gynecology, Shanghai Pudong New Area Healthcare Hospital for Women and Children, Shanghai, People's Republic of China.
Department of Obstetrics and Gynecology, Shanghai Forth People's Hospital, Shanghai, People's Republic of China.
Diabetes Metab Syndr Obes. 2023 Aug 2;16:2271-2281. doi: 10.2147/DMSO.S417632. eCollection 2023.
The aim of this study was to investigate the relationship between gestational diabetes mellitus (GDM) and Chemerin by analyzing chemerin levels in peripheral blood and cord blood, and chemerin mRNA and its protein expression in placenta and adipose tissue.
A case-control study was conducted in 110 women with GDM and 110 controls without GDM who received regular prenatal services and delivered at Shanghai Pudong New Area Healthcare Hospital for Women and Children from June 2019 to December 2020.
The age, pre-pregnancy weight, pre-pregnancy BMI, antepartum BMI, TG/HDL ratio and TG levels in pregnant women with GDM were significantly higher than those in women without GDM, and HDL levels were significantly lower than those in the normal group. Chemerin in the umbilical cord blood of the GDM group was significantly higher than in that of the normal group, but there was no difference in chemerin levels in peripheral blood. In the two groups, the chemerin concentration in peripheral blood was significantly higher than that in umbilical cord blood (P<0.001). The Chemerin mRNA and protein expression levels in the placenta and adipose tissue of pregnant women in the GDM group were significantly higher than those in the normal group (P <0.001). In the GDM group, the expression of chemerin protein in adipose tissue was significantly higher than that in placental tissue. Regression analysis showed that the expression level of chemerin protein in placental tissue and adipose tissue was positively correlated with the risk of GDM.
Elevated chemerin is closely related to the risk of GDM, and the placenta may be an important secretion of chemotactic factor sources in addition to adipose tissue and participate in the development of GDM.
本研究旨在通过分析外周血和脐血中趋化素水平，以及胎盘和脂肪组织中趋化素mRNA及其蛋白表达，探讨妊娠期糖尿病（GDM）与趋化素之间的关系。
对2019年6月至2020年12月在上海浦东新区妇幼保健院接受常规产前检查并分娩的110例GDM孕妇和110例非GDM对照孕妇进行病例对照研究。
GDM孕妇的年龄、孕前体重、孕前BMI、产前BMI、TG/HDL比值和TG水平显著高于非GDM孕妇，HDL水平显著低于正常组。GDM组脐血中趋化素显著高于正常组，但外周血中趋化素水平无差异。两组中，外周血中趋化素浓度显著高于脐血（P<0.001）。GDM组孕妇胎盘和脂肪组织中趋化素mRNA和蛋白表达水平显著高于正常组（P<0.001）。在GDM组中，脂肪组织中趋化素蛋白表达显著高于胎盘组织。回归分析表明，胎盘组织和脂肪组织中趋化素蛋白表达水平与GDM风险呈正相关。
趋化素升高与GDM风险密切相关，胎盘可能是除脂肪组织外趋化因子的重要分泌来源，并参与GDM的发生发展。
