Liang Zhaoxia, Zhou Menglin, Xu Xu-Kang, Qu Fan, Chen Danqing
a Obstetrical Department , Women's Hospital, School of Medicine, Zhejiang University , Hangzhou , China.
b School of Pharmacy and Medical Sciences, Division of Health Science , University of South Australia , Adelaide , Australia.
J Obstet Gynaecol. 2018 May;38(4):482-487. doi: 10.1080/01443615.2017.1385596. Epub 2018 Feb 12.
The present study aimed to explore the association between gestational diabetes mellitus (GDM) and Chemerin, by analysing Chemerin level, clinical data and biochemical parameters among 46 GDM patients and 43 controls. It was found that the Chemerin levels from cord blood, peripheral blood, adipose tissue and placenta tissue were all significantly higher in the GDM group than those in the control group (p < .05 for all). Maternal insulin resistance (IR) index and serum inflammation parameters, including C-reactive protein and white blood cells, were also higher in GDM group (p < .05 for all). Moreover, maternal IR index and circulating insulin level were both positively correlated with maternal circulating Chemerin level (p < .05 for both). Our findings suggest that Chemerin, associated with IR and more expressed in GDM women, might participate in the pathogenesis of GDM. Impact Statement What is already known on this subject: Chemerin, a recently-discovered adipocytokine, has been widely-considered to be involved in metabolic diseases, and several studies have investigated it in gestational diabetes mellitus (GDM), but with no consensus about the level comparison between GDM and controls. What the results of this study add: The present case-control study found that the levels of Chemerin from cord blood, peripheral blood, adipose tissue and placenta tissue were all significantly higher in the GDM group. What the implications are of these findings for clinical practice and/or further research: Also, the circulating Chemerin level was positively correlated with insulin index, which we thought would add to the evidence that Chemerin does be associated with GDM, contributing to elucidating the pathogenesis of GDM.
本研究旨在通过分析46例妊娠期糖尿病（GDM）患者和43例对照者的Chemerin水平、临床数据及生化参数，探讨妊娠期糖尿病与Chemerin之间的关联。研究发现，GDM组脐带血、外周血、脂肪组织及胎盘组织中的Chemerin水平均显著高于对照组（均p < 0.05）。GDM组孕妇的胰岛素抵抗（IR）指数及血清炎症参数（包括C反应蛋白和白细胞）也较高（均p < 0.05）。此外，孕妇IR指数及循环胰岛素水平均与孕妇循环Chemerin水平呈正相关（均p < 0.05）。我们的研究结果表明，Chemerin与IR相关且在GDM女性中表达更高，可能参与了GDM的发病机制。影响声明关于该主题已知的信息：Chemerin是一种最近发现的脂肪细胞因子，已被广泛认为与代谢性疾病有关，多项研究已在妊娠期糖尿病（GDM）中对其进行了调查，但关于GDM与对照组之间的水平比较尚无共识。本研究结果补充了什么：本病例对照研究发现，GDM组脐带血、外周血、脂肪组织及胎盘组织中的Chemerin水平均显著升高。这些发现对临床实践和/或进一步研究的意义是什么：此外，循环Chemerin水平与胰岛素指数呈正相关，我们认为这将进一步证明Chemerin确实与GDM有关，有助于阐明GDM的发病机制。
