Gholizadeh Narges, Sadeghi Azadeh, Mirzaii-Dizgah Iraj, Sheykhbahaei Nafiseh
Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Science, Tehran 14399-55991, Iran.
Department of Prosthetics, School of Dentistry, Shahid Beheshti University of Medical Science, Tehran 19839-69411, Iran.
Asian Biomed (Res Rev News). 2021 Jun 30;15(3):145-150. doi: 10.2478/abm-2021-0018. eCollection 2021 Jun.
Oral lichen planus (OLP) is one of the most common diseases in the oral cavity and has a chronic inflammatory nature. The etiology of this disease remains unclear. OLP is more prevalent in women, but to our knowledge, no study yet evaluated estrogen levels in women with OLP.
To determine the serum level of estrogen in female patients with OLP.
This case-control observational study was conducted in patients who were referred to the Department of Oral and Maxillofacial Medicine at the Tehran University of Medical Sciences. After clinical and histopathological confirmation of OLP diagnosis, and according to exclusion and inclusion criteria, 47 women with OLP and 47 healthy women (10 premenopausal and 37 postmenopausal) were included, as case and control groups, respectively. We obtained blood samples (5 mL) from each participant to measure the serum level of 17β-estradiol. Data were analyzed by Spearman rank correlation coefficients and a two-way analysis of variance with Bonferroni post hoc tests.
Serum estrogen level in women with OLP was significantly higher than that in healthy women ( = 0.002), and it was also significantly higher in premenopausal women than postmenopausal women ( < 0.001). The severity of OLP lesions correlated with estrogen level in postmenopausal women ( = 0.650; < 0.001); in premenopausal women ( = 0.618; = 0.008), and in all women with OLP ( = 0.535; < 0.001).
OLP, like other autoimmune diseases, is affected by the serum level of sex hormones such as estrogen.
口腔扁平苔藓（OLP）是口腔中最常见的疾病之一，具有慢性炎症性质。该病的病因尚不清楚。OLP在女性中更为普遍，但据我们所知，尚无研究评估OLP女性患者的雌激素水平。
测定OLP女性患者的血清雌激素水平。
本病例对照观察性研究在转诊至德黑兰医科大学口腔颌面医学系的患者中进行。在临床和组织病理学确诊OLP诊断后，根据排除和纳入标准，分别纳入47例OLP女性患者和47例健康女性（10例绝经前和37例绝经后）作为病例组和对照组。我们从每位参与者采集5毫升血液样本以测量血清17β-雌二醇水平。数据采用Spearman等级相关系数和带有Bonferroni事后检验的双向方差分析进行分析。
OLP女性患者的血清雌激素水平显著高于健康女性（P = 0.002），绝经前女性的血清雌激素水平也显著高于绝经后女性（P < 0.001）。OLP病变的严重程度与绝经后女性的雌激素水平相关（r = 0.650；P < 0.001）；在绝经前女性中（r = 0.618；P = 0.008），以及在所有OLP女性患者中（r = 0.535；P < 0.001）。
与其他自身免疫性疾病一样，OLP受雌激素等性激素血清水平的影响。
