Shiva Atena, Arab Shahin, Mousavi Seyyed Jaber, Zamanian Ali, Maboudi Avideh
Dept. of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran.
Dept. of Clinical Biochemistry, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
J Dent (Shiraz). 2020 Mar;21(1):6-11. doi: 10.30476/DENTJODS.2019.77842.
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease with unclear etiology while a few cases of disease become malignant.
This study aimed to evaluate the level of nitric oxide (NOx) and C-reactive protein (CRP) as oxidative stress and inflammation status in sample of OLP patients.
In this case-control study, serum and salivary NOx and CRP levels were evaluated in twenty two OLP patients as the case group confirmed by clinical and histopathological diagnosis, and twenty two healthy control groups collected from Tooba Oral Pathology Laboratory in Sari in 2016. The data were analyzed by using independent-samples t-test, Mann-Whitney U-test and Chi-square by using SPSS version 21. The statistical significant level was considered at < 0.05.
Salivary and serum NOx levels in case group showed statistically significantly higher than healthy control group (= 0.035 and = 0.001, respectively). CRP values were significantly higher both in serum (= 0.001) and in saliva (= 0.035). A significant correlation was found between CRP and NOx values in serum (r= 0.521, = 0.0001) and saliva (r= 0.427, = 0.045).
Oxidative stress causes damage to organs in the human body. Correct understanding of oxidative stress and its association with free radicals and inflammatory markers related to oral disease are important for effective treatments. The results of the study advocate the effects of NOx and CRP levels in pathogenesis of OLP. Therefore, antioxidant drugs might probably be considered in the treatment of OLP.
口腔扁平苔藓（OLP）是一种病因不明的慢性炎症性口腔黏膜疾病，少数病例会发生恶变。
本研究旨在评估一氧化氮（NOx）和C反应蛋白（CRP）水平，以了解OLP患者样本中的氧化应激和炎症状态。
在这项病例对照研究中，对22例经临床和组织病理学诊断确诊的OLP患者作为病例组，以及2016年从萨里的图巴口腔病理学实验室收集的22例健康对照组，评估其血清和唾液中的NOx和CRP水平。使用SPSS 21版通过独立样本t检验、曼-惠特尼U检验和卡方检验对数据进行分析。统计学显著性水平设定为<0.05。
病例组的唾液和血清NOx水平在统计学上显著高于健康对照组（分别为P = 0.035和P = 0.001）。血清（P = 0.001）和唾液（P = 0.035）中的CRP值均显著更高。血清中CRP与NOx值之间存在显著相关性（r = 0.521，P = 0.0001），唾液中也存在显著相关性（r = 0.427，P = 0.045）。
氧化应激会对人体器官造成损害。正确理解氧化应激及其与自由基和口腔疾病相关炎症标志物的关联对于有效治疗很重要。该研究结果表明了NOx和CRP水平在OLP发病机制中的作用。因此，在OLP治疗中可能应考虑使用抗氧化药物。
