一种假定的第二种T细胞受体的鉴定。
Identification of a putative second T-cell receptor.
作者信息
Brenner M B, McLean J, Dialynas D P, Strominger J L, Smith J A, Owen F L, Seidman J G, Ip S, Rosen F, Krangel M S
出版信息
Nature. 1986;322(6075):145-9. doi: 10.1038/322145a0.
DOI:10.1038/322145a0
PMID:3755221
Abstract
Framework monoclonal antibodies have identified a population of human lymphocytes that express the T3 glycoprotein but not the T-cell receptor (TCR) alpha- and beta-subunits. Chemical crosslinking experiments reveal that these lymphocytes express novel T3-associated polypeptides, one of which appears to be the product of the T gamma gene. The other polypeptide may represent a fourth TCR subunit, designated T delta.
摘要
构架单克隆抗体已鉴定出一群人类淋巴细胞，这些细胞表达T3糖蛋白，但不表达T细胞受体（TCR）的α和β亚基。化学交联实验表明，这些淋巴细胞表达新的T3相关多肽，其中一种似乎是Tγ基因的产物。另一种多肽可能代表第四个TCR亚基，命名为Tδ。
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