Cruz Jessica, McCarthy Fiona
University of Arizona, Tucson, Arizona, United States.
Animal Comparative and Biomedical Sciences, University of Arizona.
MicroPubl Biol. 2025 Jun 24;2025. doi: 10.17912/micropub.biology.001584. eCollection 2025.
Scavenger Receptor (SCAR) genes are a heterogeneous group involved in innate immunity and immunomodulation. While standardized gene nomenclature is provided for model organism SCAR genes, ungulates have novel SCAR genes which have not been systematically classified. This study compares SCAR genes for five representative ungulate species which are selected based on their agricultural importance and representation. We identify and classify twenty-seven SCAR genes common to all species and provide standardized gene nomenclature for genes novel to these ungulate species. Notably, we provide standardized gene nomenclature for the previously studied Workshop Cluster 1 (WC1) genes which are absent in model organisms.
清道夫受体（SCAR）基因是一组参与天然免疫和免疫调节的异质性基因。虽然已为模式生物的SCAR基因提供了标准化的基因命名法，但有蹄类动物有一些尚未被系统分类的新型SCAR基因。本研究比较了五个具有代表性的有蹄类物种的SCAR基因，这些物种是根据它们在农业上的重要性和代表性来选择的。我们鉴定并分类了所有物种共有的27个SCAR基因，并为这些有蹄类物种的新型基因提供了标准化的基因命名法。值得注意的是，我们为之前研究的模式生物中不存在的第1工作组（WC1）基因提供了标准化的基因命名法。
