Nillius S J, Wide L
Ups J Med Sci. 1979;84(1):21-35. doi: 10.3109/03009737909179137.
Nine amenorrhoeic women with anorexia nervosa (AN) were given long-term treatment with 500 microgram of synthetic luteinizing hormone-releasing hormone (LRH) every 8 h. All the women had impaired luteinizing hormone (LH) secretion and no evidence of endogenous oestrogen production. Three of them also had deficient follicle-stimulating hormone (FSH) secretion. The pituitary reserve capacity for gonadotrophin secretion was normal but the response pattern to LRH was similar to that described in prepubertal girls. The constant administration of LRH normalized basal LH and FSH secretion and induced a cyclical gonadotrophin secretory pattern with differential changes of the LH and FSH responses to LRH during the treatment. LRH-induced gonadotrophin secretion produced follicular growth and maturation in all the women. Presumptive ovulation also occurred during the 8 treatment courses in which only LRH was administered. However, inadequate luteal phases were observed during 6 of these 8 cycles. Combined therapy with LRH and human chorionic gonadotrophin (HCG) during 5 treatment courses resulted in normal ovulatory cycles with adequate corpus luteum function.
对9名神经性厌食症（AN）所致闭经的女性患者进行了长期治疗，每8小时给予500微克合成促黄体生成素释放激素（LRH）。所有女性患者促黄体生成素（LH）分泌均受损，且无内源性雌激素生成的证据。其中3人促卵泡刺激素（FSH）分泌也不足。垂体促性腺激素分泌的储备能力正常，但对LRH的反应模式与青春期前女孩相似。持续给予LRH可使基础LH和FSH分泌正常化，并在治疗期间诱导出促性腺激素分泌的周期性模式，LH和FSH对LRH的反应有差异变化。LRH诱导的促性腺激素分泌使所有女性患者卵泡生长并成熟。在仅给予LRH的8个疗程治疗期间也出现了推测的排卵。然而，在这8个周期中的6个周期观察到黄体期不足。在5个疗程治疗期间，LRH与人绒毛膜促性腺激素（HCG）联合治疗导致排卵周期正常，黄体功能良好。
