Department of Medicine, McMaster University, Hamilton, Canada.
Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada.
PLoS One. 2023 Aug 8;18(8):e0289540. doi: 10.1371/journal.pone.0289540. eCollection 2023.
The single breath diffusion capacity for carbon monoxide (DLCO) captures several aspects of the role of the lung in meeting the metabolic demands of the body. The magnitude of the independent contributors to the DLCO is unknown. The aim of this study was to investigate the factors that independently contribute to the DLCO.
The objective was to investigate the impact of height, age, sex and haemoglobin on DLCO, alveolar volume (VA) and carbon monoxide transfer coefficient (KCO).
Study participants were pre-screened based on normal exercise capacity achieved during an incremental cardio-pulmonary exercise testing (CPET) using cycle ergometry at McMaster University Medical Center between 1988-2012. Participants who had an FEV1>80% predicted, with an FEV1/FVC ≥0.7 and who achieved a maximum power output ≥80% were selected for analysis. In total, 16,298 subjects [61% male, mean height 1.70m (range 1.26-2.07), age 49 yrs (10-94), weight 79 kg (23-190) had DLCO measured while demonstrating normal spirometry and exercise capacity.
The DLCO increased exponentially with height, was 15% greater in males, increased with age yearly until 20, then decreased yearly after the age of 35, and was 6% higher per gram of haemoglobin (5.58Height(m)1.691.15 in Males*(1-0.006Age>35)(1+0.01*Age<20) (1+0.06Hb gm/dl), (r = 0.76).
Height, age, sex, and haemoglobin all have independent influence on the DLCO in subjects with normal spirometry and preserved exercise capacity.
一氧化碳单次呼吸弥散量（DLCO）可反映肺在满足机体代谢需求方面的多个方面。但目前尚不清楚哪些因素对 DLCO 的影响是独立的。本研究旨在探讨哪些因素对 DLCO 有独立影响。
探讨身高、年龄、性别和血红蛋白对 DLCO、肺泡容积（VA）和一氧化碳传递系数（KCO）的独立影响。
研究参与者是根据 1988 年至 2012 年期间在麦克马斯特大学医学中心使用功率自行车进行递增心肺运动测试（CPET）时所达到的正常运动能力进行初步筛选的。筛选条件为：FEV1 占预计值的百分比>80%，FEV1/FVC ≥0.7，最大功输出≥80%。共有 16298 名受试者[61%为男性，平均身高 1.70m（范围 1.26-2.07），年龄 49 岁（10-94 岁），体重 79kg（23-190kg）]的 DLCO 测量值正常，且其肺活量和运动能力也正常。
DLCO 与身高呈指数增长，男性比女性高 15%，其随年龄增长，直至 20 岁时每年增加，然后从 35 岁起每年下降，血红蛋白每增加 1g/dl 则增加 6%[男性：5.58身高（m）1.691.15，Males*（1-0.006年龄>35）（1+0.01年龄<20）（1+0.06*血红蛋白（g/dl）]，相关系数（r）为 0.76。
在肺功能正常且运动能力正常的受试者中，身高、年龄、性别和血红蛋白对 DLCO 均有独立影响。
