Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, SK, Canada
Dept of Internal Medicine, University of Genoa, Genoa, Italy.
Eur Respir J. 2017 Jan 3;49(1). doi: 10.1183/13993003.00016-2016. Print 2017 Jan.
This document provides an update to the European Respiratory Society (ERS)/American Thoracic Society (ATS) technical standards for single-breath carbon monoxide uptake in the lung that was last updated in 2005. Although both D (diffusing capacity) and T (transfer factor) are valid terms to describe the uptake of carbon monoxide in the lung, the term D is used in this document. A joint taskforce appointed by the ERS and ATS reviewed the recent literature on the measurement of D and surveyed the current technical capabilities of instrumentation being manufactured around the world. The recommendations in this document represent the consensus of the taskforce members in regard to the evidence available for various aspects of D measurement. Furthermore, it reflects the expert opinion of the taskforce members on areas in which peer-reviewed evidence was either not available or was incomplete. The major changes in these technical standards relate to D measurement with systems using rapidly responding gas analysers for carbon monoxide and the tracer gas, which are now the most common type of D instrumentation being manufactured. Technical improvements and the increased capability afforded by these new systems permit enhanced measurement of D and the opportunity to include other optional measures of lung function.
本文件对 2005 年最后更新的欧洲呼吸学会（ERS）/美国胸科学会（ATS）肺一氧化碳单呼吸量测定技术标准进行了更新。虽然 D（弥散量）和 T（转移因子）都是描述肺内一氧化碳摄取的有效术语，但本文件中使用了 D 术语。ERS 和 ATS 联合任命的一个工作组审查了关于 D 测量的最新文献，并调查了目前世界各地制造的仪器的技术能力。本文件中的建议代表了工作组对 D 测量各个方面的现有证据的共识。此外，它还反映了工作组就那些没有经过同行评审或证据不完整的领域的专家意见。这些技术标准的主要变化涉及使用快速响应一氧化碳气体分析仪和示踪气体的系统进行 D 测量，这些系统现在是制造的最常见的 D 仪器类型。技术改进和这些新系统提供的更高性能允许增强 D 的测量，并提供了包括其他可选肺功能测量的机会。
