蝙蝠感染组织胞浆菌属。
Infection of bats with Histoplasma species.
机构信息
Professor of Medical Mycology (Retired), Department of Microbiology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
Manchester Fungal Infection Group, School of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
出版信息
Med Mycol. 2023 Aug 2;61(8). doi: 10.1093/mmy/myad080.
Histoplasma species infect humans and animals, notably bats. Histoplasma species are thermally dimorphic fungi existing in mycelial form in the natural environment and in yeast form in infected tissues. In this narrative literature review, we summarize the occurrence of Histoplasma spp. in different species of bat tissues (n = 49) and in soil admixed with bat guano where the species of bat dwelling nearby has been identified (an additional 18 species likely infected) to provide an up-to-date summary of data. Most positive isolations are from the Americas and Caribbean, with some studies from Thailand, Malaysia, Nigeria, Slovenia, France, and Australia. We also summarize some of the early experimental work to elucidate pathogenicity, latency, immune response, and faecal excretion in bats. Given the recent recognition of the global extent of histoplasmosis, thermal dimorphism in Histoplasma spp., and global heating, additional work on understanding the complex relationship between Histoplasma and bats is desirable.
组织胞浆菌属物种感染人类和动物，尤其是蝙蝠。组织胞浆菌属是热双相真菌，在自然环境中以菌丝形式存在，在感染组织中以酵母形式存在。在本次叙述性文献综述中，我们总结了不同种类蝙蝠组织（n=49）和混合有蝙蝠粪便的土壤中组织胞浆菌属的发生情况，这些土壤中居住的蝙蝠种类已经被确定（另外还有 18 种可能被感染），以提供最新的数据汇总。大多数阳性分离株来自美洲和加勒比地区，也有一些来自泰国、马来西亚、尼日利亚、斯洛文尼亚、法国和澳大利亚的研究。我们还总结了一些早期的实验工作，以阐明蝙蝠中的致病性、潜伏期、免疫反应和粪便排泄。鉴于组织胞浆菌病在全球范围内的广泛存在、组织胞浆菌属的热二相性以及全球变暖，有必要进一步研究了解组织胞浆菌与蝙蝠之间复杂的关系。
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