Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Research, Innovation and Partnerships Office, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.
BMC Complement Med Ther. 2023 Aug 8;23(1):282. doi: 10.1186/s12906-023-04098-2.
Hypertension is among the risk factors of death globally. Novel antihypertensive peptides are alternative choices of antihypertensive assistance. This study aimed to discover novel antihypertensive peptides from green basil leaves. Two bioactive peptides with high angiotensin-converting enzyme inhibition (Asp-Leu-Ser-Ser-Ala-Pro; peptide 1) and antioxidant (Asp-Ser-Val-Ser-Ala-Ser-Pro; peptide 2) activities were gavaged to male Wistar rats induced with N-nitro-l-arginine methyl-ester (L-NAME). L-NAME-treated rats (HT) had decreased body weights and levels of nitrite and nitrate, which are metabolites of nitric oxide. The levels of their glucose and liver function indicators increased as compared to normal rats. HT rats receiving antihypertensive drugs (HTD) showed higher low-density lipoprotein and low-density lipoprotein/high-density lipoprotein levels than HT rats. Peptide 1 seems to benefit the rat lipid profiles, liver functions, antioxidant, nitrite, nitrate, and angiotensin II peptide levels but not peptide 2. In conclusion, our findings indicate the antihypertensive potential related to vasodilation of peptides from green basil leaves.
高血压是全球死亡的风险因素之一。新型抗高血压肽是抗高血压辅助治疗的另一种选择。本研究旨在从绿罗勒叶中发现新型的抗高血压肽。两种具有高血管紧张素转化酶抑制（Asp-Leu-Ser-Ser-Ala-Pro；肽 1）和抗氧化活性（Asp-Ser-Val-Ser-Ala-Ser-Pro；肽 2）的生物活性肽被灌胃给予用 N-硝基-L-精氨酸甲酯（L-NAME）诱导的雄性 Wistar 大鼠。L-NAME 处理的大鼠（HT）体重和亚硝酸盐和硝酸盐水平降低，亚硝酸盐和硝酸盐是一氧化氮的代谢物。与正常大鼠相比，它们的葡萄糖和肝功能指标水平升高。接受抗高血压药物的 HT 大鼠（HTD）的低密度脂蛋白和低密度脂蛋白/高密度脂蛋白水平高于 HT 大鼠。与肽 2 相比，肽 1 似乎有益于大鼠的脂质谱、肝功能、抗氧化、亚硝酸盐、硝酸盐和血管紧张素 II 肽水平。总之，我们的研究结果表明，绿罗勒叶来源的肽具有血管舒张相关的降压潜力。
