Maderazo E G, Berlin B B, Morhardt C
Urology. 1979 Jan;13(1):70-3. doi: 10.1016/0090-4295(79)90020-7.
A case is described of malakoplakia involving the urinary tract and retroperitoneum with recalcitrant infection due to Escherichia coli which was not responsive to seemingly appropriate antibiotics and surgery for drainage, but which subsequently responded to treatment with trimethoprim-sulfamethoxazole. It is speculated that this drug combination may be helpful because of the ability of trimethoprim to enhance the killing of viable undigested microorganisms inside malakoplakic macrophages.
本文描述了一例累及泌尿道和腹膜后的软斑病病例,该病例因大肠杆菌感染顽固,对看似合适的抗生素及引流手术均无反应,但随后对甲氧苄啶-磺胺甲恶唑治疗有反应。据推测,这种药物组合可能有帮助,因为甲氧苄啶能够增强对软斑病巨噬细胞内存活的未消化微生物的杀伤作用。