Lemieux G
Can Med Assoc J. 1974 Apr 20;110(8):910-2.
Thirty-nine subjects with active non-obstructive urinary tract infection due to common pathogens were treated in a randomized fashion either with sulfamethoxazole alone (22 patients) or a combination of trimethoprim-sulfamethoxazole (17 patients) during four consecutive weeks in the course of a controlled study. The combination trimethoprim-sulfamethoxazole appeared more effective than sulfamethoxazole alone in eradicating infection. Complete disappearance of urinary tract infection was obtained in 82% of subjects treated with the combination versus 59% in those treated with sulfamethoxazole alone. Recurrence of infection averaged 43% in the group treated with the combination and 54% in those treated with sulfamethoxazole alone. The mean time interval between successful response and recurrence of infection was 17 weeks for the combination and 20 weeks for sulfamethoxazole alone. When the comparison of the results between sulfamethoxazole alone and the combination trimethoprim-sulfamethoxazole is restricted to the subjects with E. coli infection (69% of all cases), no important difference between the two groups can be demonstrated. A skin rash which sometimes disappeared spontaneously despite continued medication was the only side effect noted with the trimethoprim-sulfamethoxazole combination.
在一项对照研究过程中，39例因常见病原体引起的活动性非梗阻性尿路感染患者被随机分为两组，连续四周分别接受单独使用磺胺甲恶唑治疗（22例患者）或甲氧苄啶 - 磺胺甲恶唑联合治疗（17例患者）。甲氧苄啶 - 磺胺甲恶唑联合治疗在根除感染方面似乎比单独使用磺胺甲恶唑更有效。联合治疗的患者中有82%的尿路感染完全消失，而单独使用磺胺甲恶唑治疗的患者中这一比例为59%。联合治疗组感染复发率平均为43%，单独使用磺胺甲恶唑治疗组为54%。联合治疗组成功治愈至感染复发的平均时间间隔为17周，单独使用磺胺甲恶唑治疗组为20周。当仅比较单独使用磺胺甲恶唑和甲氧苄啶 - 磺胺甲恶唑联合治疗大肠杆菌感染患者（占所有病例的69%）的结果时，两组之间未发现重要差异。甲氧苄啶 - 磺胺甲恶唑联合治疗唯一观察到的副作用是出现皮疹，有时皮疹即使在持续用药的情况下也会自行消失。
