Centre for Cell Biology & Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
J Pathol. 2023 Aug;260(5):609-620. doi: 10.1002/path.6159. Epub 2023 Aug 8.
Fibroblasts are the major cell population of connective tissue, including the skin dermis, and are best known for their function in depositing and remodelling the extracellular matrix. Besides their role in extracellular matrix homeostasis, fibroblasts have emerged as key players in many biological processes ranging from tissue immunity and wound healing to hair follicle development. Recent advances in single-cell RNA-sequencing technologies have revealed an astonishing transcriptional fibroblast heterogeneity in the skin and other organs. A key challenge in the field is to understand the functional relevance and significance of the identified new cell clusters in health and disease. Here, we discuss the functionally distinct fibroblast subtypes identified in skin homeostasis and repair and how they evolve in fibrotic disease conditions, in particular keloid scars and cancer. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
成纤维细胞是结缔组织的主要细胞群体，包括皮肤真皮，它们最著名的功能是沉积和重塑细胞外基质。除了在细胞外基质稳态中的作用外，成纤维细胞还在许多生物学过程中发挥关键作用，从组织免疫和伤口愈合到毛囊发育。单细胞 RNA 测序技术的最新进展揭示了皮肤和其他器官中成纤维细胞惊人的转录异质性。该领域的一个关键挑战是理解在健康和疾病中鉴定的新细胞簇的功能相关性和意义。在这里，我们讨论了在皮肤稳态和修复中鉴定的功能不同的成纤维细胞亚型，以及它们在纤维化疾病条件下（特别是瘢痕疙瘩和癌症）如何演变。
