Department of Internal Medicine, Takara Clinic, Nagano, Japan.
Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
J Diabetes Investig. 2023 Nov;14(11):1237-1245. doi: 10.1111/jdi.14064. Epub 2023 Aug 8.
AIMS/INTRODUCTION: The association between serum uric acid (SUA) levels and prediabetes risk remains poorly understood. The aim of this longitudinal retrospective study was to evaluate the association between SUA levels and prediabetes progression in Japanese individuals through sex-specific analysis.
We enrolled 20,743 participants (11,916 men and 8,827 women) who underwent annual medical health checkups in 2017 (baseline) and 2022. None of the participants had diabetes and prediabetes or were taking SUA-lowering medications at baseline. Participants were divided into four groups according to the quartiles of SUA levels at baseline. Multivariable-adjusted Cox regression analysis was conducted to examine the risk of prediabetes progression. In addition, multivariate restricted cubic spline analysis was conducted to investigate the dose-response risk.
In women, compared with the lowest SUA quartile (Q1) group, the adjusted hazard ratios (95% confidence intervals) of prediabetes in the Q2, Q3, and Q4 groups were 1.03 (0.86-1.25), 1.41 (1.18-1.68), and 1.55 (1.30-1.84), respectively. However, in men, no significant association in the risk of prediabetes was found across quartiles of SUA. Furthermore, in women, restricted cubic spline analysis revealed the dose-response relationship between SUA and progression to prediabetes.
The results indicate that elevated serum SUA levels might be positively and independently associated with an increased risk of progression to prediabetes in Japanese women.
目的/引言：血清尿酸（SUA）水平与糖尿病前期风险之间的关系仍不清楚。本纵向回顾性研究的目的是通过性别特异性分析，评估日本人群中 SUA 水平与糖尿病前期进展之间的关系。
我们纳入了 20743 名参与者（男性 11916 名，女性 8827 名），他们在 2017 年（基线）和 2022 年进行了年度体检。所有参与者在基线时均无糖尿病和糖尿病前期，也未服用降低 SUA 的药物。根据基线时 SUA 水平的四分位数，将参与者分为四组。采用多变量调整的 Cox 回归分析来评估糖尿病前期进展的风险。此外，还进行了多变量限制立方样条分析，以探讨剂量反应风险。
在女性中，与最低 SUA 四分位（Q1）组相比，Q2、Q3 和 Q4 组糖尿病前期的调整后的危险比（95%置信区间）分别为 1.03（0.86-1.25）、1.41（1.18-1.68）和 1.55（1.30-1.84）。然而，在男性中，SUA 四分位组之间的糖尿病前期风险无显著相关性。此外，在女性中，限制立方样条分析显示了 SUA 与进展为糖尿病前期之间的剂量反应关系。
结果表明，血清 SUA 水平升高可能与日本女性糖尿病前期进展的风险增加呈正相关且独立相关。
