Department of Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
Invest Ophthalmol Vis Sci. 2020 Sep 1;61(11):10. doi: 10.1167/iovs.61.11.10.
The purpose of this study was to investigate the relationship between high intraocular pressure (IOP) and uric acid.
In a retrospective cross-sectional study, 19,147 participants were included in 2018. Serum uric acid (SUA) was cut to four groups as Q1 to Q4, according to the quartiles. The odds ratio (OR) and 95% confidence interval (CI) of different SUA levels were estimated by a binomial logistic regression model in men and women. A restrictive cubic spline method was used to estimate the dose-response relationship between uric acid and high IOP. Subgroup analysis was performed to find the gender-specific association between uric acid and high IOP.
In women, after adjusting for confounding factors, the Q3 and Q4 of SUA levels were significantly associated with the risk of high IOP. The OR with 95% CI for Q3 and Q4 were 1.77 (1.22, 2.57) and 1.51 (1.01, 2.26), respectively, Q1 as a reference. For men, SUA levels were not associated with the incidence of high IOP. Moreover, the spline analysis found an inverted U-shaped relationship between uric acid and high IOP in women (P = 0.0171).
Elevated levels of SUAwere independently associated with an increased risk of high IOP in women, but not in men. In addition, uric acid had an inverse U-shaped nonlinear dose-response relationship with high IOP in women.
本研究旨在探讨眼内压（IOP）与尿酸之间的关系。
在 2018 年进行的一项回顾性横断面研究中，纳入了 19147 名参与者。根据四分位数，将血清尿酸（SUA）分为 Q1 至 Q4 四个组。采用二项逻辑回归模型估计不同 SUA 水平的比值比（OR）及其 95%置信区间（CI）。采用限制性三次样条法估计尿酸与高 IOP 之间的剂量反应关系。进行亚组分析以确定尿酸与高 IOP 之间的性别特异性关联。
在女性中，调整混杂因素后，SUA 水平的 Q3 和 Q4 与高 IOP 的风险显著相关。Q3 和 Q4 的 OR（95%CI）分别为 1.77（1.22，2.57）和 1.51（1.01，2.26），Q1 为参考。对于男性，SUA 水平与高 IOP 的发生率无关。此外，样条分析发现女性尿酸与高 IOP 之间呈倒 U 形关系（P = 0.0171）。
SUA 水平升高与女性高 IOP 的风险增加独立相关，但与男性无关。此外，女性尿酸与高 IOP 之间存在反向 U 形非线性剂量反应关系。
