Cheng Wai-Yin, Desmet Louis, Depoortere Inge
Translational Research Center for Gastrointestinal Disorders, Gut Peptide Research Lab, University of Leuven, Leuven, Belgium.
Acta Physiol (Oxf). 2023 Oct;239(2):e14027. doi: 10.1111/apha.14027. Epub 2023 Aug 8.
The circadian timing system enables organisms to adapt their physiology and behavior to the cyclic environmental changes including light-dark cycle or food availability. Misalignment between the endogenous circadian rhythms and external cues is known as chronodisruption and is closely associated with the development of metabolic and gastrointestinal disorders, cardiovascular diseases, and cancer. Time-restricted eating (TRE, in human) is an emerging dietary approach for weight management. Recent studies have shown that TRE or time-restricted feeding (TRF, when referring to animals) has several beneficial health effects, which, however, are not limited to weight management. This review summarizes the effects of TRE/TRF on regulating energy metabolism, gut microbiota and homeostasis, development of cardiovascular diseases and cancer. Furthermore, we will address the role of circadian clocks in TRE/TRF and propose ways to optimize TRE as a dietary strategy to obtain maximal health benefits.
昼夜节律系统使生物体能够使其生理和行为适应包括明暗周期或食物供应在内的周期性环境变化。内源性昼夜节律与外部线索之间的失调被称为生物钟紊乱，并且与代谢和胃肠道疾病、心血管疾病以及癌症的发生密切相关。限时进食（在人类中）是一种新兴的体重管理饮食方法。最近的研究表明，限时进食（TRE）或限时喂养（TRF，指动物时）具有多种有益健康的作用，然而，这些作用并不局限于体重管理。本综述总结了限时进食/限时喂养对调节能量代谢、肠道微生物群和体内平衡、心血管疾病和癌症发展的影响。此外，我们将探讨生物钟在限时进食/限时喂养中的作用，并提出优化限时进食作为一种饮食策略以获得最大健康益处的方法。
