Bakhsh Jomanah, Salvy Sarah-Jeanne, Vidmar Alaina P
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA USA.
Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Los Angeles, CA USA.
NPJ Metab Health Dis. 2024;2(1):39. doi: 10.1038/s44324-024-00041-2. Epub 2024 Dec 30.
Intermittent fasting focuses on the timing of eating rather than diet quality or energy intake, with evidence supporting its effects on weight loss and improvements in cardiometabolic outcomes in adults with obesity. However, there is limited evidence for its feasibility and efficacy in young people. To address this, a scoping review was conducted to examine intermittent fasting regimens in individuals aged 10 to 25 for the treatment of obesity focusing on methodology, intervention parameters, outcomes, adherence, feasibility, and efficacy. Due to the paucity of evidence in this age group, to adequately assess feasibility and adherence, all published studies of intermittent fasting in this age category, regardless of weight status and treatment intention, were included in the review. The review included 34 studies (28 interventional studies and 6 observational studies) with 893 participants aged 12 to 25. Interventions varied with 9 studies in cohorts with obesity utilizing intermittent fasting as an obesity treatment. Thirteen studies utilized 8-h time-restricted eating. Primary outcomes included cardiometabolic risk factors (7/28), anthropometric measurements (7/28), body composition (5/28), muscular performance (4/28), feasibility (1/28), and others (4/28). All 9 studies conducted in young people with obesity reported some degree of weight loss, although the comparator groups varied significantly. This review underscores the various utilizations of intermittent fasting in this age group and highlights its potential in treating obesity. However, the findings emphasize the need for rigorous studies with standardized frameworks for feasibility to ensure comparability and determine intermittent fasting's practicality in this age group depending on the treatment outcome of interest.
间歇性禁食关注的是进食时间,而非饮食质量或能量摄入,有证据支持其对肥胖成年人的体重减轻及心血管代谢指标改善的作用。然而,关于其在年轻人中的可行性和有效性的证据有限。为解决这一问题,开展了一项范围综述,以研究10至25岁个体用于治疗肥胖的间歇性禁食方案,重点关注方法学、干预参数、结果、依从性、可行性和有效性。由于该年龄组证据匮乏,为充分评估可行性和依从性,该综述纳入了此年龄类别中所有已发表的间歇性禁食研究,无论体重状况和治疗意图如何。该综述纳入了34项研究(28项干预性研究和6项观察性研究),共893名年龄在12至25岁的参与者。干预措施各不相同,9项针对肥胖队列的研究将间歇性禁食用作肥胖治疗方法。13项研究采用了8小时限时进食。主要结果包括心血管代谢危险因素(7/28)、人体测量指标(7/28)、身体成分(5/28)、肌肉性能(4/28)、可行性(1/28)以及其他(4/28)。在所有针对肥胖年轻人开展的9项研究中,均报告了一定程度的体重减轻,尽管对照组差异很大。本综述强调了间歇性禁食在该年龄组的多种应用,并突出了其在治疗肥胖方面的潜力。然而,研究结果强调需要开展具有标准化框架的严格研究以确保可行性,从而保证可比性,并根据感兴趣的治疗结果确定间歇性禁食在该年龄组的实用性。